Phthalate exposure and reproductive hormones in adult men
Phthalate exposure and reproductive hormones in adult men
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DOI：
10.1093/humrep/deh656
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发表时间：
2005-03-01
影响因子：
6.1
通讯作者：
Hauser, R
中科院分区：
文献类型：
--
作者：
Duty, SM;Calafat, AM;Hauser, R
背景技术：邻苯二甲酸酯用于个人和消费品，食品包装材料和聚氯乙烯塑料，并已在美国大多数普通人群中进行了测量。一致的实验证据表明，一些邻苯二甲酸酯对动物的发育和生殖有毒。这项研究探讨了邻苯二甲酸酯的环境水平与成年男性生殖激素水平改变之间的关系。方法：1999年至2003年，从马萨诸塞州总医院招募了295名男性。在尿液中测定选定的邻苯二甲酸酯代谢物。线性回归模型探讨了比重调整的尿邻苯二甲酸单酯浓度与生殖激素（包括FSH、LH、性激素结合球蛋白、睾酮和白蛋白B）血清水平之间的关系。研究结果：邻苯二甲酸单苄酯（MBzP）暴露量的四分位距（IQR）变化与FSH浓度降低10% [95%置信区间（CI）：-16，-4.0]显著相关。此外，邻苯二甲酸单丁酯（MBP）暴露的IQR变化与白藜芦醇B增加4.8%（95% CI：0，10）相关，但这具有临界显著性。结论：虽然我们发现尿中MBP和MBzP浓度与FSH和BABIN B水平的改变有关，但激素浓度并未按预期模式变化。因此，目前尚不清楚这些关联是否代表这些激素的生理相关变化，或者它们是否代表进行多重比较后发现的关联。
BACKGROUND: Phthalates are used in personal and consumer products, food packaging materials, and polyvinyl chloride plastics and have been measured in the majority of the general population of the USA. Consistent experimental evidence shows that some phthalates are developmental and reproductive toxicants in animals. This study explored the association between environmental levels of phthalates and altered reproductive hormone levels in adult men. METHODS: Between 1999 and 2003, 295 men were recruited from Massachusetts General Hospital. Selected phthalate metabolites were measured in urine. Linear regression models explored the relationship between specific gravity-adjusted urinary phthalate monoester concentrations and serum levels of reproductive hormones, including FSH, LH, sex hormone-binding globulin, testosterone, and inhibin B. RESULTS: An interquartile range (IQR) change in monobenzyl phthalate (MBzP) exposure was significantly associated with a 10% [95% confidence interval (CI): -16, -4.0] decrease in FSH concentration. Additionally, an IQR change in monobutyl phthalate (MBP) exposure was associated with a 4.8% (95% CI: 0, 10) increase in inhibin B but this was of borderline significance. CONCLUSIONS: Although we found associations between MBP and MBzP urinary concentrations and altered levels of inhibin B and FSH, the hormone concentrations did not change in the expected patterns. Therefore, it is unclear whether these associations represent physiologically relevant alterations in these hormones, or whether they represent associations found as a result of conducting multiple comparisons.