Focal adhesion assembly
Focal adhesion assembly
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DOI：
10.1016/s0962-8924(97)01127-6
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发表时间：
1997-09-01
影响因子：
19
通讯作者：
Zhong, CL
中科院分区：
文献类型：
--
作者：
Burridge, K;ChrzanowskaWodnicka, M;Zhong, CL
GTP结合蛋白Rho调节局部粘连及其相关的肌动蛋白细丝束的组装。两条不同的研究路线汇聚在一起，揭示了Rho可能如何调控这些结构的组装。一种方法是确定Rho下游效应器，而另一种方法是探索伸缩剂促进组装的作用。现在很明显，Rho是基于肌动球蛋白的非肌肉细胞收缩的关键调节因子，收缩能力与与刚性底物的粘连相结合，倾向于形成应力纤维和局灶性粘连。
The GTP-binding protein Rho regulates the assembly of focal adhesions and their associated bundles of actin filaments. Two different lines of research have converged to reveal how Rho might regulate assembly of these structures. One approach has been the identification of downstream effectors of Rho, whereas the other has been the exploration of the role of contractility ist promoting assembly. It is now apparent that Rho is a key regulator of actomyosin-based contractility in nonmuscle cells and that contractility, combined with adhesion to a rigid substrate, leans to the formation of both stress fibres and focal adhesions.