Effect of case definition on affective disorder rates.
Effect of case definition on affective disorder rates.
复制标题
病例定义对情感障碍发生率的影响。
DOI：
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发表时间：
1981
影响因子：
17.7
通讯作者：
N. Andreasen
中科院分区：
文献类型：
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作者：
W. Coryell;G. Winokur;N. Andreasen
在由美国国立精神卫生研究所临床研究处抑郁症精神生物学合作项目进行的一项初步分析中，对1090名患有抑郁症和躁狂症先证者的受访亲属进行调查，结果发现爱荷华州情感性疾病的终生患病率明显低于其他四个研究中心。在各种情感障碍诊断中，只有原发性单相抑郁症在爱荷华州的发病率显著较低。随着病例定义的限制越来越严格，这种发病率的差异逐渐减小。爱荷华州抑郁症发病率低的可能决定因素将被研究；目前的数据说明了病例定义在解释未来研究结果中的重要性。
In a preliminary analysis by the NIMH-Clinical Research Branch Collaborative Program on the Psychobiology of Depression the lifetime rate of affective illness among 1,090 interviewed relatives of depressed and manic probands was considerably lower in Iowa than in the other four centers. Among various affective disorder diagnoses, only primary unipolar depression was significantly less frequent in Iowa. This rate difference decreased with increasingly restrictive case definitions. Possible determinants of the low depression rate in Iowa will be investigated; the present data illustrate the importance of case definition in the interpretation of future findings.