THE EFFECTS OF ACUTE AND CHRONIC ETHANOL ADMINISTRATION AND ITS WITHDRAWAL ON γ‐AMINOBUTYRIC ACID RECEPTOR BINDING IN RAT BRAIN
THE EFFECTS OF ACUTE AND CHRONIC ETHANOL ADMINISTRATION AND ITS WITHDRAWAL ON γ‐AMINOBUTYRIC ACID RECEPTOR BINDING IN RAT BRAIN
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急性和长期乙醇给药及其停药对大鼠脑内γ-氨基丁酸受体结合的影响
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发表时间：
1980
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通讯作者：
M. Ticku
中科院分区：
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作者：
M. Ticku
1观察急性和慢性乙醇灌胃及戒断对大鼠脑内抑制性神经递质γ-氨基丁酸结合的影响。2急性乙醇(2~4g/kg ip.脑切除前30分钟)可增加低亲和力GABA受体结合部位的结合能力。3慢性乙醇灌胃(1~21d)后，GABA受体结合特性无明显变化。这些结果表明，GABA受体可能对GABA突触上乙醇的持续存在进行了适应。4酒精戒断后8h和16h，低亲和力GABA受体结合部位的亲和力显著低于配对喂养对照组。5这些结果提示，GABA受体敏感性可能在乙醇的某些神经药理作用及其戒断症状中起作用。
1 The effects of acute and chronic ethanol administration, and withdrawal on the binding of the inhibitory neurotransmitter, γ‐aminobutyric acid (GABA), was investigated in rat brain. 2 Acute ethanol (2 to 4 g/kg i.p. 30 min before removal of brain) produced an increase in the binding capacity of the low affinity GABA receptor binding site. 3 Following chronic ethanol administration (1 to 21 days), the GABA receptor binding characteristics were not altered. These results suggest a possible adaptation of GABA receptors to the continuous presence of ethanol at the GABA synapse. 4 During ethanol withdrawal, the affinity of the low affinity GABA receptor binding site was significantly lower than pair‐fed controls at 8 and 16 h withdrawal. 5 These results suggest that GABA receptor sensitivity may play a role in some of the neuropharmacological effects of ethanol and in its withdrawal symptoms.