DESCRIPTION OF A MURINE MODEL OF EXPERIMENTAL HEPATIC METASTASES
DESCRIPTION OF A MURINE MODEL OF EXPERIMENTAL HEPATIC METASTASES
复制标题
DOI：
10.1093/jnci/77.3.823
复制
发表时间：
1986-09-01
影响因子：
10.3
通讯作者：
HOLYOKE, ED
中科院分区：
文献类型：
--
作者：
GOLDROSEN, MH;PAOLINI, N;HOLYOKE, ED
建立了小鼠实验性肝转移瘤模型。盲肠经中线切口外切1.5次。将105个MCA-38肝源性肿瘤细胞0.1 ml注入回结肠静脉（ICV）。98%的注射微转移瘤在第11天首次被检测到。剖腹探查21天，平均发现肝灶18个。注射ICV后35天可触诊到实验性肝转移灶。携带MCA-38 LD病灶的小鼠平均存活53.3天。该模型将用于开发治疗肝转移的新方法。
A murine model of experimental hepatic metastases has been developed. The cecum is exteriorized through a midline incision, and 1.5 .times. 105 MCA-38 liver-derived (LD) tumor cells in 0.1 ml was injected into the ileocolic vein (ICV). Ninety-eight percent of injected icrometastases could first be detected on day 11. Laparotomy of 21 days revealed the presence of a mean of 18 hepatic foci. Experimental hepatic metastases could be palpated 35 days following ICV injection. Mice bearing MCA-38 LD foci survived an average of 53.3 days. This model will be of use in the development of novel approaches for the treatment of hepatic metastasis.