Long-lasting treatment for moderate-severe depressed facial scars: skin and hair derived new autologous tissue filler with subcision
Long-lasting treatment for moderate-severe depressed facial scars: skin and hair derived new autologous tissue filler with subcision
复制标题
中重度凹陷性面部疤痕的持久治疗：皮肤和头发衍生的新型自体组织填充物和皮下切除术
DOI：
10.1080/09546634.2020.1748854
复制
发表时间：
2020-04-03
影响因子：
2.9
通讯作者：
Zhang, Qingguo
中科院分区：
文献类型：
--
作者：
Chen, Qi;Yang, Yue;Zhang, Qingguo
背景资料：组织填充物注射是一种常用的组织填充方法，但由于现有材料的局限性，其在凹陷性瘢痕矫正中的应用还不广泛。目的：本研究旨在观察自体皮肤和毛发来源的组织工程填充物对中重度凹陷性瘢痕的修复效果。患者与方法：40例中重度凹陷性瘢痕患者自愿参加研究。取自体毛发和一小块皮肤的角蛋白凝胶和成纤维细胞与自体血清混合，然后注射到畸形的真皮中。注射的整个过程是：充分切除后填充并平整10%的瘢痕，每隔3周重复治疗，共9周。收集并评估不同时间点瘢痕的临床特征。结果如下：36例患者完全遵循方案，治疗后1年瘢痕深度和大小至少改善50%（显著改善），其中88.9%的患者改善75%或以上（极好改善）。未报告严重并发症。结论：自体角蛋白和成纤维细胞作为填充物是治疗中重度凹陷性瘢痕的有效选择，具有长期疗效和较高的满意度。
Background: Tissue filler injection is popular for tissue augmentation, but it is still not widely used for depressed scar correction because of the limitations of the existed materials. Objective: This study was designed to observe the effects of a tissue-engineering filler derived from autologous skin and hairs for correction of moderate-severe depressed scars. Patients and methods: Totally 40 volunteers with moderate-severe depressed scars were enrolled in. Keratin gel and fibroblast derived from autologous hairs and a small piece of skin were mixed with autoserum and then injected into the dermis of the deformities. The whole procedure for injection was: filling and leveling up the scars by 10% after adequate subcision and repeating the treatment every other 3 weeks for total 9 weeks. Clinical features at different time points of the scars were collected and assessed. Results: Thirty-six patients followed the protocol completely, receiving at least 50% improvement in depth and size of scars (significant improvement) 1 year after the treatment, with 88.9% of them had '75% improvement or more improvement' (excellent improvement). No severe complications were reported. Conclusion: Autologous keratin and fibroblast as filler is an effective option for moderate-severe depressed scars correction with long-term efficacy and high satisfactory.