Dopaminergic reward system: a short integrative review.
Dopaminergic reward system: a short integrative review.
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DOI：
10.1186/1755-7682-3-24
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发表时间：
2010-10-06
期刊：
影响因子：
--
通讯作者：
Pöppel E
中科院分区：
文献类型：
--
作者：
Arias-Carrión O;Stamelou M;Murillo-Rodríguez E;Menéndez-González M;Pöppel E
记忆是适应性行为的一个基本要素，因为它可以巩固过去的经验，引导受试者在未来的经验中考虑它们。多巴胺是参与记忆巩固的内源性分子之一，包括被认为是一种学习形式的药物寻求奖励。这种神经递质调节特定的脑核团的活动，例如核团，壳核，腹侧被盖区（VTA）等，并抑制这些核团的活动，以建立神经生物学机制来设置学习的享乐元素。我们回顾了实验证据，突出了不同的脑核团的活动，调节机制，使多巴胺偏见的记忆对事件的动机意义。
Memory is an essential element to adaptive behavior since it allows consolidation of past experience guiding the subject to consider them in future experiences. Among the endogenous molecules that participate in the consolidation of memory, including the drug-seeking reward, considered as a form of learning, is dopamine. This neurotransmitter modulates the activity of specific brain nucleus such as nuclei accumbens, putamen, ventral tegmental area (VTA), among others and synchronizes the activity of these nuclei to establish the neurobiological mechanism to set the hedonic element of learning. We review the experimental evidence that highlights the activity of different brain nuclei modulating the mechanisms whereby dopamine biases memory towards events that are of motivational significance.