[Epidemiological study of Staphylococcus aureus isolated from the Japanese National University and Medical College Hospitals with coagulase typing, and production of enterotoxins and toxic shock syndrome toxin-1].
[Epidemiological study of Staphylococcus aureus isolated from the Japanese National University and Medical College Hospitals with coagulase typing, and production of enterotoxins and toxic shock syndrome toxin-1].
复制标题
日本国立大学和医科大学附属医院分离金黄色葡萄球菌凝固酶分型及产生肠毒素和中毒性休克综合征毒素1的流行病学研究
DOI：
10.11150/kansenshogakuzasshi1970.66.1543
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
T. Otsuka
中科院分区：
文献类型：
--
作者：
A. Kimura;H. Igarashi;H. Ushioda;K. Okuzumi;Hiroyoshi Kobayashi;T. Otsuka
对430株沙门氏菌进行了凝血酶分型、肠毒素（SE）A ~ E或中毒性休克综合征毒素-1（TSST = 1）的产生及苯唑西林（MPIPC）敏感性的检测。金黄色葡萄球菌，于1990年8月的一个月内从43个日本国立大学或医学院医院的临床样本中分离出来。耐甲氧西林金黄色葡萄球菌（MRSA）：在含2%NaCl的Mueller-Hinton肉汤中对MPIPC的最低抑菌浓度大于4 mmg/ml，占所有菌株的58.6%;金黄色葡萄球菌，和超过60%的菌株，从入院的病人在所有地区的日本除了北海道。产凝固酶II型、SEC和TSST-1的菌株最多，占MRSA总数的34.5%。这类菌株主要分布在本州岛东部，尤其在东北和中部地区表现出较高的比例。第二常见的耐甲氧西林金黄色葡萄球菌是凝固酶II型，不产生SE或TSST-1，占15.4%，主要分布在日本西部地区。产凝固酶IV、SEA的MRSA和产凝固酶II、SEA、SEC和TSST-1的MRSA检出率较高，分别为10.3%和8.7%。凝固酶III型，没有SE，也没有TSST-1生产MRSA表现出特征性的分布，只在日本西部地区检测到，四国岛的发病率最高。
Coagulase typing, staphylococcus enterotoxins (SE) A to E or toxic shock syndrome toxin-1 (TSST = 1) production, and susceptibility to Oxacillin (MPIPC) were examined in 430 strains of S. aureus, which were isolated from clinical specimen of 43 Japanese National University or Medical College Hospitals during the one month period of August in 1990. Methicillin-resistant Staphylococcus aureus (MRSA): more than 4 mmg/ml of minimum inhibitory concentration for MPIPC in Mueller-Hinton broth containing 2% NaCl, occupied 58.6% of all the S. aureus, and more than 60% of the strains from admitted patients in all the areas of Japan except Hokkaidoh. Coagulase type II, SEC and TSST-1 producing strains were most frequently detected, 34.5% of all the MRSA. This kind of strain was distributed mainly in the eastern part of the Honshyu island, and showed high percentage especially in the Tohhoku and the Chyubu area. The second most frequent kind of MRSA was coagulase type II, no SE nor TSST-1 producing one, 15.4%, which was distributed mainly in the western part of Japan. Coagulase type IV, SEA producing MRSA strains and Coagulase type II, SEA, SEC and TSST-1 producing strains were detected in relatively high incidence, 10.3% and 8.7% respectively. Coagulase type III, no SE nor TSST-1 producing MRSAs demonstrated characteristic distribution, and were detected only in the western part of Japan, presenting the highest incidence in the Shikoku Island.