Steroid-Induced Ocular Hypertensive Response in Children and Adolescents With Acute Lymphoblastic Leukemia and Non-Hodgkin Lymphoma
Steroid-Induced Ocular Hypertensive Response in Children and Adolescents With Acute Lymphoblastic Leukemia and Non-Hodgkin Lymphoma
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DOI：
10.1002/pbc.25070
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发表时间：
2014-11-01
影响因子：
3.2
通讯作者：
Cipolotti, Rosana
中科院分区：
文献类型：
--
作者：
Mendonca, Cristiano de Queiroz;de Souza Junior, Cristiano Prado;Cipolotti, Rosana
本研究的目的是评估儿童和青少年急性淋巴细胞白血病和非霍奇金淋巴瘤治疗中与糖皮质激素使用相关的眼内压（IOP）。我们进行了一项前瞻性描述性研究，测量了治疗前（D 0）、治疗第8天（D8）、第14天（D14）和治疗第28小时（D28）的IOP。我们检查了12例患者，其中2例为高眼压，发现D 0与D8和D 0与D14之间的IOP均值之间存在统计学显著差异（P=0.013）。无症状性高眼压伴不可逆性失明的可能性提示有必要对眼压进行验证。儿科血液癌症2014;61：2083-2085。(c)2014 Wiley Periodicals，Inc.
The aim of this study was to evaluate intraocular pressure (IOP) associated with use of glucocorticoids in children and adolescents treated for acute lymphoblastic leukemia and non-Hodgkin lymphoma. We carried out a prospective descriptive study with measurement of IOP before treatment (D0), 8th (D8), 14th (D14), and 28h days (D28) of treatment. We examined 12 patients, with two cases of ocular hypertension, and it was found a statistically significant difference between the means of IOP between D0 versus D8 and D0 versus D14 (P=0.013). The possibility of silent ocular hypertension with irreversible blindness indicates the need of IOP verification. Pediatr Blood Cancer 2014;61:2083-2085. (c) 2014 Wiley Periodicals, Inc.