Quantitative Method for assessing One Symptom of the Withdrawal Syndrome in Mice after Chronic Morphine Administration
Quantitative Method for assessing One Symptom of the Withdrawal Syndrome in Mice after Chronic Morphine Administration
复制标题
评估慢性吗啡给药后小鼠戒断综合征一种症状的定量方法
作者：
I. Marshall;M. Weinstock
很少有定量的方法来评估从成瘾的实验动物身上戒断吗啡的效果。这里描述的实验的目的是评估一种依赖于小鼠在吗啡戒断1后所做的特征性垂直跳跃次数的方法是否可以用作戒断综合征的测量。这种简单的方法现在已经被发现可以给出合理的可重复和一致的结果。
FEW quantitative methods exist for assessing the effects of withdrawing morphine from addicted laboratory animals. The aim of the experiments described here was to assess whether a method which depends on the number of characteristic vertical jumps made by mice after morphine withdrawal1 could be used as a measure of the withdrawal syndrome. This simple method has now been found to give reasonably repeatable and consistent results.