Mechanical Properties of Natural Cartilage and Tissue-Engineered Constructs
Mechanical Properties of Natural Cartilage and Tissue-Engineered Constructs
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DOI：
10.1089/ten.teb.2010.0572
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发表时间：
2011-08-01
影响因子：
6.4
通讯作者：
Chen, Xiongbiao
中科院分区：
文献类型：
--
作者：
Little, Christopher James;Bawolin, Nahshon Kenneth;Chen, Xiongbiao
在过去的二十年里，人们进行了大量的研究，目的是设计软骨结构来修复或恢复受损的软骨。为了设计健康的新软骨，结构必须具有与天然软骨相匹配的机械性能，并且适合关节的负载条件。本文讨论了天然软骨的机械行为，并调查了不同类型的拉伸、压缩和剪切测试及其局限性。它还全面回顾了最近在开发代表天然软骨和工程软骨机械性能的数学模型方面的工作和成就。还讨论了增强工程软骨机械性能的不同方法，包括支架设计、机械刺激和化学刺激。本文最后对未来的研究提出了建议，旨在实现机械性能与天然软骨相匹配的工程软骨。
There has been much research over the past two decades with the aim of engineering cartilage constructs for repairing or restoring damaged cartilage. To engineer healthy neocartilage, the constructs must have mechanical properties matching those of native cartilage as well as appropriate for the loading conditions of the joint. This article discusses the mechanical behavior of native cartilage and surveys different types of tensile, compressive, and shear tests with their limitations. It also comprehensively reviews recent work and achievements in developing the mathematical models representing the mechanical properties of both native and engineered cartilage. Different methods for enhancing the mechanical properties of engineered cartilage are also discussed, including scaffold design, mechanical stimulation, and chemical stimulation. This article concludes with recommendations for future research aimed at achieving engineered cartilage with mechanical properties matching those found in native cartilage.