The in-betweeners: MAIT cells join the innate-like lymphocytes gang.
The in-betweeners: MAIT cells join the innate-like lymphocytes gang.
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中间者：MAIT 细胞加入了先天性淋巴细胞群。
DOI：
10.1084/jem.2118insight3
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Margulies,DavidH
中科院分区：
文献类型：
--
作者：
Margulies,DavidH
< ID> jem. 2118insight2fig1. jpeg A key challenge at the intestinal barrier is to minimize responses to commensal bacteria, which can lead to inflammatory bowel disease (IBD) in genetically predisposed individuals, but retain the ability to recognize and control the growth of infectious pathogens. Group 3 innate lymphoid cells (ILC3) help maintain intestinal homeostasis by producing the cytokine IL-22, which promotes mucosal healing and maintains barrier integrity. Microbial signals trigger production of IL-23 and IL-1, which stimulate ILC3s to produce IL-22, leading to the induction of antibacterial peptides and epithelial cell regeneration. But the identity of the cell type producing IL-23 in response to microbial signals is unclear and has been the subject of much debate; resident mononuclear phagocytes, inflammatory monocytes, and conventional dendritic cells have all been implicated. In this issue, Longman et al. provide compelling evidence, both in mouse following Citrobacter rodentium infection and in patients with colitis, that CX3CR1+ mononuclear phagocytes (MNPs) are the most potent producers of IL-23 and IL-1 and are very efficient in inducing IL-22 production by ILC3.< doi> 10.1 084/je m. 2 118i ns ig ht 2< aid> je m. 2 118i ns ig ht 2< au> Gi orgi o Trin chieri< AF1> Natio nal C ancer Institut e, Na tio nal In stitu tes of H ealth< cor> trinchig@ mail. nih. gov< dochead> In sights< doctopic> New s Critical role for CX 3
