Human T ‐cell leukemia virus type I associated lymphadenitis
Human T ‐cell leukemia virus type I associated lymphadenitis
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人类T细胞白血病病毒I型相关淋巴结炎
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
N. Kimura
中科院分区：
文献类型：
--
作者：
K. Ohshima;M. Kikuchi;Y. Masuda;Y. Sumiyoshi;F. Eguchi;H. Mohtai;M. Takeshita;N. Kimura
Histopathologic changes in lymph nodes were examined from ten patients with mild lymphadenopathy, a few atypical lymphocytes in their peripheral blood, skin lesions, and proviral DNA of human T‐cell leukemia virus type I (HTLV‐I) in their nodes. The proviral DNA of HTLV‐I was detected by southern blot analysis, in situ hybridization, and/or polymerase chain reaction techniques. The lymph nodes showed preserved nodal architecture with diffuse infiltration of small to intermediate‐sized lymphocytes in association with scattered transformed lymphocytes and a few immunoblast‐like cells in the enlarged paracortex. The infiltrating lymphocytes were positive for CD4, but neither rearrangement nor deletion of T‐cell receptors and immunoglobulin heavy chain genes was detected. Eight of ten patients received no therapy, and all patients were alive and healthy more than 5 months after the biopsies. The histologic findings resembled those of a viral infection and could be distinguished from HTLV‐I associated lymphomas.
霍奇金病涉及的淋巴结和脾脏细胞成分的原位免疫学特征。
影响因子：
20.3
作者：
Poppema,S;Bhan,AK;Reinherz,EL;Posner,MR;Schlossman,SF
通讯作者：
Schlossman,SF