Noradrenergic and serotonergic fibers innervate complementary layers in monkey primary visual cortex: an immunohistochemical study.
Noradrenergic and serotonergic fibers innervate complementary layers in monkey primary visual cortex: an immunohistochemical study.
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去甲肾上腺素能和血清素能纤维支配猴子初级视觉皮层的互补层：一项免疫组织化学研究。
DOI：
10.1073/pnas.79.7.2401
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发表时间：
1982
影响因子：
11.1
通讯作者：
Lidov,HG
中科院分区：
文献类型：
--
作者：
Morrison,JH;Foote,SL;Molliver,ME;Bloom,FE;Lidov,HG
抗人多巴胺β-羟化酶或5-羟色胺的抗血清被用来表征去甲肾上腺素能和肾上腺素能神经支配模式内的初级视觉皮层的松鼠猴。去甲肾上腺素能和去甲肾上腺素能投射表现出高度的层状互补性：第V层和第VI层接收密集的去甲肾上腺素能投射和非常稀疏的去甲肾上腺素能投射，而第IV层接收非常密集的去甲肾上腺素能投射，并且基本上没有去甲肾上腺素能纤维。此外，去甲肾上腺素能纤维表现出几何顺序，这在肾上腺素能纤维的分布中并不那么明显。这些模式的神经支配意味着，这两个递质系统影响不同阶段的皮层信息处理中缝皮层的神经元投射优先支配的多刺星状细胞的层IVa和IVc，而ceruleo皮质去甲肾上腺素能投射支配锥体细胞。
Antisera directed against human dopamine beta-hydroxylase or serotonin were used to characterize the noradrenergic and serotonergic innervation patterns within the primary visual cortex of the squirrel monkey. The noradrenergic and serotonergic projections exhibit a high degree of laminar complementarity: layers V and VI receive a dense noradrenergic projection and a very sparse serotonergic projection, whereas layer IV receives a very dense serotonergic projection and is largely devoid of noradrenergic fibers. In addition, the noradrenergic fibers manifest a geometric order that is not so readily apparent in the distribution of serotonergic fibers. These patterns of innervation imply that the two transmitter systems affect different stages of cortical information processing--the raphe-cortical serotonergic projection preferentially innervates the spiny stellate cells of layers IVa and IVc, whereas the ceruleo-cortical noradrenergic projection innervates pyramidal cells.