Evolution of Molecular Targeted Cancer Therapy: Mechanisms of Drug Resistance and Novel Opportunities Identified by CRISPR-Cas9 Screening.
Evolution of Molecular Targeted Cancer Therapy: Mechanisms of Drug Resistance and Novel Opportunities Identified by CRISPR-Cas9 Screening.
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分子靶向癌症治疗的演变：耐药机制和 CRISPR-Cas9 筛选发现的新机会
DOI：
10.3389/fonc.2022.755053
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发表时间：
2022
影响因子：
4.7
通讯作者：
Zheng X
中科院分区：
文献类型：
--
作者：
Hou J;He Z;Liu T;Chen D;Wang B;Wen Q;Zheng X
由于更好的治疗反应和更少的全身毒性，分子靶向治疗已经彻底改变了癌症治疗的格局。然而，治疗耐药性是临床环境中的一个主要挑战，阻碍了癌症患者的持续临床益处。在这方面，解开耐药机制可能会为分子靶向治疗发现新的可用药的基因改变，从而有助于提高治疗效果。最近，包括CRISPR-CAS9筛查技术和患者衍生模型在内的新方法的快速发展为剖析靶向癌症治疗耐药的潜在机制提供了强大的工具。在这篇综述中，我们更新了正在进行临床前和临床评估的各种癌症类型的治疗目标。更重要的是，我们提供了高通量CRISPR-Cas9筛选在破译分子靶向治疗无效的潜在机制方面的全面阐述，这将为设计下一代抗癌药物提供新的机会的发现。
Molecular targeted therapy has revolutionized the landscape of cancer treatment due to better therapeutic responses and less systemic toxicity. However, therapeutic resistance is a major challenge in clinical settings that hinders continuous clinical benefits for cancer patients. In this regard, unraveling the mechanisms of drug resistance may identify new druggable genetic alterations for molecularly targeted therapies, thus contributing to improved therapeutic efficacies. The recent rapid development of novel methodologies including CRISPR-Cas9 screening technology and patient-derived models provides powerful tools to dissect the underlying mechanisms of resistance to targeted cancer therapies. In this review, we updated therapeutic targets undergoing preclinical and clinical evaluation for various cancer types. More importantly, we provided comprehensive elaboration of high throughput CRISPR-Cas9 screening in deciphering potential mechanisms of unresponsiveness to molecularly targeted therapies, which will shed light on the discovery of novel opportunities for designing next-generation anti-cancer drugs.
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影响因子：
7.4
作者：
Brignone C;Gutierrez M;Mefti F;Brain E;Jarcau R;Cvitkovic F;Bousetta N;Medioni J;Gligorov J;Grygar C;Marcu M;Triebel F
通讯作者：
Triebel F
影响因子：
--
作者：
Casara P;Davidson J;Claperon A;Le Toumelin-Braizat G;Vogler M;Bruno A;Chanrion M;Lysiak-Auvity G;Le Diguarher T;Starck JB;Chen I;Whitehead N;Graham C;Matassova N;Dokurno P;Pedder C;Wang Y;Qiu S;Girard AM;Schneider E;Gravé F;Studeny A;Guasconi G;Rocchetti F;Maïga S;Henlin JM;Colland F;Kraus-Berthier L;Le Gouill S;Dyer MJS;Hubbard R;Wood M;Amiot M;Cohen GM;Hickman JA;Morris E;Murray J;Geneste O
通讯作者：
Geneste O
影响因子：
8.4
作者：
Bokemeyer, Carsten;Van Cutsem, Eric;Koehne, Claus-Henning
通讯作者：
Koehne, Claus-Henning
影响因子：
45.3
作者：
Ahmed, Nabil;Brawley, Vita S.;Gottschalk, Stephen
通讯作者：
Gottschalk, Stephen
影响因子：
64.8
作者：
Burr ML;Sparbier CE;Chan YC;Williamson JC;Woods K;Beavis PA;Lam EYN;Henderson MA;Bell CC;Stolzenburg S;Gilan O;Bloor S;Noori T;Morgens DW;Bassik MC;Neeson PJ;Behren A;Darcy PK;Dawson SJ;Voskoboinik I;Trapani JA;Cebon J;Lehner PJ;Dawson MA
通讯作者：
Dawson MA