Re(de)fining Innate Lymphocyte Lineages in the Face of Cancer.
Re(de)fining Innate Lymphocyte Lineages in the Face of Cancer.
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DOI：
10.1158/2326-6066.cir-17-0440
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发表时间：
2018-04
影响因子：
10.1
通讯作者：
Li MO
中科院分区：
文献类型：
--
作者：
Chou C;Li MO
先天性淋巴细胞在维持宿主稳态和致病性损伤期间的组织稳态和完整性方面起关键作用。新的先天淋巴细胞亚群的连续鉴定揭示了该家族内令人难以置信的多样性。虽然这种异质性群体可以根据其细胞毒性潜力分为专门产生精氨酸的辅助细胞和细胞溶解性杀伤细胞，但亚群之间的确切发育关系尚未完全了解。前一组在粘膜表面富集，而具有细胞毒性潜力的先天性淋巴细胞可以在更广泛的组织中鉴定，包括肿瘤。虽然它们的细胞毒性表明具有抗肿瘤作用，但肿瘤引起的先天性淋巴细胞反应的性质才刚刚开始研究，参与亚群的身份仍然存在争议。在这篇综述中，我们提供了一个简要的概述先天淋巴细胞生物学，审查目前的知识，对他们的个体发育，并讨论他们在肿瘤免疫监视的作用。
Innate lymphocytes play critical roles in maintaining tissue homeostasis and integrity of the host at steady state and during pathogenic insults. The successive identification of new innate lymphocyte subsets has revealed an incredible diversity within the family. While this heterogeneous population can be grouped based on their cytotoxic potential into exclusively cytokine-producing helpers and cytolytic killers, the exact developmental relationships between the subsets are not fully understood. The former group is enriched at mucosal surfaces, whereas innate lymphocytes with cytotoxic potential can be identified in a wider array of tissues, including tumors. Although their cytotoxicity suggests an antitumor role, the nature of tumor-elicited innate lymphocyte responses has only begun to be investigated and the identities of participating subsets still remain contentious. In this review, we provide a brief overview of innate lymphocyte biology, review the current knowledge on their ontogeny, and discuss their roles in tumor immunosurveillance.