Mutagenicity, toxicity and repair of DNA base damage induced by oxidation
Mutagenicity, toxicity and repair of DNA base damage induced by oxidation
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DOI：
10.1016/j.mrfmmm.2003.07.002
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发表时间：
2003-10-29
影响因子：
2.3
通讯作者：
Seeberg, E
中科院分区：
文献类型：
--
作者：
Bjelland, S;Seeberg, E
氧化性DNA损伤是所有需氧生物中细胞死亡和诱变的主要原因，近年来已经鉴定出几种新的氧化性碱基损伤。改进的化学合成的寡核苷酸与修饰的碱基残基在确定的位置，允许详细的研究修复，复制，转录和诱变在特定的病变在体外和体内。本综述的目的是介绍迄今为止已知的所有各种已知的氧化DNA碱基病变的结构，并总结有关氧化碱基修饰及其修复的致突变和毒性作用的现有知识。(C)2003 Elsevier B.V.保留所有权利。
Oxidative DNA damage is a major cause of cell death and mutagenesis in all aerobic organisms, and several new oxidative base lesions have been identified in recent years. Improved chemistry for the synthesis of oligonucleotides with modified base residues at defined positions has allowed detailed studies of repair, replication, transcription and mutagenesis at specific lesions in vitro and in vivo. The aim of this review is to present the structure of all the various known oxidised DNA base lesions known to date and to summarise the present knowledge about the mutagenic and toxic effects of oxidised base modifications and their repair. (C) 2003 Elsevier B.V. All rights reserved.