(-)-3,5-dicaffeoyl-muco-quinic acid isolated from Aster scaber contributes to the differentiation of PC12 cells:: through tyrosine kinase cascade signaling
(-)-3,5-dicaffeoyl-muco-quinic acid isolated from Aster scaber contributes to the differentiation of PC12 cells:: through tyrosine kinase cascade signaling
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DOI：
10.1016/j.bbrc.2003.11.178
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发表时间：
2004-01-23
影响因子：
3.1
通讯作者：
Kim, SY
中科院分区：
文献类型：
--
作者：
Hur, JY;Lee, P;Kim, SY
紫菀（菊科）已被用于传统的韩国和中国医药治疗瘀伤，蛇咬伤，头痛，头晕。(-)-3，5-二咖啡酰粘奎尼酸（DQ）是从A. scaber诱导PC 12细胞突起生长。研究表明，细胞外信号调节激酶12（Erk 12）和磷酸肌醇3（P13）激酶的激活在神经生长因子诱导的PC 12细胞分化中起重要作用。这项研究表明，DQ对神经突起生长的影响是通过Erk 1/2和P13激酶依赖性途径介导的，如NGF。此外，DQ还能促进Trk A的磷酸化。总的来说，DQ通过Trk A磷酸化随后Erk 1/2和P13激酶激活引起PC 1/2细胞的分化。(C)2003年爱思唯尔公司All rights reserved.
Aster scaber T. (Asteraceae) has been used in traditional Korean and Chinese medicine to treat bruises, snakebites, headaches, and dizziness. (-)-3,5-Dicaffeoyl-muco-quinic acid (DQ) isolated from A. scaber induced neurite outgrowth in PC12 cells. It has been reported that the activation of the extracellular signal regulated kinase 1/2 (Erk 1/2) and phosphoinositide 3 (P13) kinase plays a crucial role in the NGF-induced differentiation of PC12 cells. This study showed that the effect of DQ on neurite outgrowth is mediated via the Erk 1/2 and P13 kinase-dependent pathways like NGF. Furthermore, DQ stimulated the phosphorylation of Trk A. Overall, DQ elicited the differentiation of PC12 cells through Trk A phosphorylation followed by Erk 1/2 and P13 kinase activation. (C) 2003 Elsevier Inc. All rights reserved.