A β-hairpin peptide with pH-controlled affinity for tumor cells
A β-hairpin peptide with pH-controlled affinity for tumor cells
复制标题
一种对肿瘤细胞具有 pH 控制亲和力的 β-发夹肽
DOI：
10.1039/d1cc06218b
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发表时间：
2022
影响因子：
4.9
通讯作者：
Tanaka Masaru
中科院分区：
文献类型：
--
作者：
Nishimura Shin-nosuke;Nishida Kei;Tanaka Masaru
考虑到肿瘤微环境中pH的失调，我们设计了一种β-发夹多肽(SSRFEWEFESSDPRGDPSSRFEWEFESS)。在弱酸性条件下，多肽的构型从柔性线状结构转变为刚性环状结构。在弱酸性条件下，肿瘤细胞内化的多肽显著增加。
Considering that the pH in the tumor microenvironment is dysregulated, we designed a β-hairpin peptide (SSRFEWEFESSDPRGDPSSRFEWEFESS). The configuration of the peptide switched from a flexible linear to a rigid loop structure under weakly acidic conditions. The peptide internalized by tumor cells increased significantly under weakly acidic conditions.