Intercellular communication capacity as a possible determinant of transformation sensitivity of BALB/c 3T3 clonal cells.
Intercellular communication capacity as a possible determinant of transformation sensitivity of BALB/c 3T3 clonal cells.
复制标题
细胞间通讯能力可能是 BALB/c 3T3 克隆细胞转化敏感性的决定因素。
作者：
H. Yamasaki;T. Enomoto;Y. Shiba;Y. Kanno;T. Kakunaga
虽然对紫外线辐射和苯并(a)芘诱导的转化具有高和低敏感性的 BALB/c 3T3 克隆细胞变体在生长阶段表现出相似的细胞间通讯能力，但仅在对转化敏感的克隆变体细胞汇合时才会发生通讯的显着损失。 12-O-tetradecanoylphorbol-13-acetate 是一种有效的肿瘤促进剂，它还能增强甲基胆蒽诱导的 BALB/c 3T3 细胞转化，并以类似的程度抑制这些变体的细胞间通讯。这些结果表明，细胞间通讯控制的内在差异可能是这些变体对诱导转化的敏感性的决定因素。
While clonal cell variants of BALB/c 3T3 with high and low susceptibilities to ultraviolet radiation- and benzo(a)pyrene-induced transformation show similar intercellular communication capacities when they are in the growing phase, a significant loss in communication occurs at confluence only in transformation-sensitive clonal variant cells. A potent tumor promoter, 12-O-tetradecanoylphorbol-13-acetate, which also enhances BALB/c 3T3 cell transformation induced by methylcholanthrene, inhibited intercellular communication of these variants to a similar extent. These results suggest that intrinsic differences in the control of intercellular communication may be a determinant of the susceptibility of these variants to the induction of transformation.
12-O tetradecanoylphorbol-13-acetate 破坏晚期癌前人类结肠上皮细胞之间的通讯。
影响因子：
11.2
作者：
Friedman,EA;Steinberg,M
通讯作者：
Steinberg,M