Methodologic Issues When Estimating Risks in Pharmacoepidemiology.
Methodologic Issues When Estimating Risks in Pharmacoepidemiology.
复制标题
DOI：
10.1007/s40471-016-0089-1
复制
发表时间：
2016-12-01
影响因子：
3.3
通讯作者：
Lesko, Catherine R
中科院分区：
文献类型：
--
作者：
Edwards, Jessie K;Hester, Laura L;Lesko, Catherine R
风险是描述一段时间内健康结果发生情况的重要参数。然而，在医疗保健环境中，许多令人感兴趣的结果，如疾病发生率、治疗启动和特定原因的死亡率，可能会被其他事件排除在外，这些事件通常被称为竞争事件。在这里，我们回顾了在竞争事件存在的情况下估计风险的直接方法。我们用及时的例子说明这些方法在药物流行病学研究中的应用，并将结果与通常用于处理竞争事件的分析简化所获得的结果进行比较。这些例子说明了用于解释竞争事件的分析方法如何影响药物流行病学研究结果的解释。
Risk is an important parameter to describe the occurrence of health outcomes over time. However, many outcomes of interest in healthcare settings, such as disease incidence, treatment initiation, and cause-specific mortality, may be precluded from occurring by other events, often referred to as competing events. Here, we review straightforward approaches to estimate risk in the presence of competing events. We illustrate the application of these methods using timely examples in pharmacoepidemiologic research and compare results to those obtained using analytic simplifications commonly used to handle competing events. These examples demonstrate how the analytic methods used to account for competing events affect the interpretation of results from pharmacoepidemiologic studies.