The epithelium takes centre stage in asthma and atopic dermatitis
The epithelium takes centre stage in asthma and atopic dermatitis
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DOI：
10.1016/j.it.2007.04.007
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发表时间：
2007-06-01
影响因子：
16.8
通讯作者：
Holgate, Stephen T.
中科院分区：
文献类型：
--
作者：
Holgate, Stephen T.
哮喘和特应性皮炎是上皮疾病，其中辅助性T细胞2（Th2）型炎症具有突出作用。胸腺基质淋巴细胞生成素（TSLP）是由皮肤和气道上皮产生的细胞因子，其能够将树突状细胞导向Th2应答，从而提供上皮细胞活化和过敏型炎症之间的重要联系。此外，TSLP可以直接与肥大细胞相互作用，启动Th2细胞因子的产生，也提供了一个非T细胞途径来介导其促过敏作用。TSLP产生的诱导通过上皮Toll样受体的活化而发生，以提供先天免疫和过敏性疾病之间的重要新联系。
Asthma and atopic dermatitis are epithelial disorders in which T helper 2 (Th2)-type inflammation has a prominent role. Thymic stromal lymphopoietin (TSLP) is a cytokine produced by the skin and airway epithelium that is capable of directing dendritic cells towards a Th2 response, thereby providing an essential link between epithelial cell activation and allergic-type inflammation. In addition, TSLP can interact directly with mast cells to initiate Th2 cytokine production to also provide a non-T cell route to mediate its pro-allergic effects. Induction of TSLP production occurs through the activation of epithelial Toll-like receptors to provide an important new link between innate immunity and allergic disease.