Correlation of lung tumor motion with external surrogate indicators of respiration
Correlation of lung tumor motion with external surrogate indicators of respiration
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DOI：
10.1016/j.ijrobp.2004.07.681
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发表时间：
2004-11-15
影响因子：
7
通讯作者：
Pignol, JP
中科院分区：
文献类型：
--
作者：
Hoisak, JDP;Sixel, KE;Pignol, JP
目的：评估呼吸量和腹部位移与 X 射线透视下肿瘤运动的相关性。在患者整个治疗过程中进行的测量可以评估这种相关性的分次间再现性。方法和材料：数据来自 11 名患者；对 5 项进行了多天的研究。通过肺活量测定法测量的呼吸量和通过实时位置跟踪系统测量的腹部位移与同时获得的上下肿瘤位移的 X 射线透视测量结果相关。计算每次数据采集的线性相关系数。通过互相关延迟分析估计替代信号和肿瘤信号之间的相位关系。结果：相关系数范围从非常高到非常低（0.99-0.39，p < 0.0001）。肿瘤位移与呼吸量之间的相关性比肿瘤位移与腹部位移之间的相关性更高且更可重复。几乎所有患者都观察到非零相位关系（-0.65 至 +0.50 s）。观察到这种关系在分次间和分次内时间尺度上变化。经过多天研究的 5 名患者中，只有 1 名患者的肿瘤运动与任一替代指标之间存在一致的关系。结论：呼吸量与肿瘤运动的相关性比腹部位移的相关性更高。如果根据有限的一系列观察结果形成肿瘤替代预测模型，则使用替代来指导治疗可能会导致地理失误。 (C) 2004 年爱思唯尔公司。
Purpose: To assess the correlation of respiratory volume and abdominal displacement with tumor motion as seen with X-ray fluoroscopy. Measurements throughout the patient's treatment course allowed an assessment of the interfractional reproducibility of this correlation.Methods and Materials: Data were acquired from 11 patients; 5 were studied over multiple days. Measurements of respiratory volume by spirometry and abdominal displacement by a real-time position tracking system were correlated to simultaneously acquired X-ray fluoroscopy measurements of superior-inferior tumor displacement. The linear correlation coefficient was computed for each data acquisition. The phase relationship between the surrogate and tumor signals was estimated through cross-correlation delay analysis.Results: Correlation coefficients ranged from very high to very low (0.99-0.39, p < 0.0001). The correlation between tumor displacement and respiratory volume was higher and more reproducible from day to day than between tumor displacement and abdominal displacement. A nonzero phase relationship was observed in nearly all patients (-0.65 to +0.50 s). This relationship was observed to vary over inter- and intrafractional time scales. Only 1 of 5 patients studied over multiple days had a consistent relationship between tumor motion and either surrogate.Conclusions: Respiratory volume has a more reproducible correlation with tumor motion than does abdominal displacement. If forming a tumor-surrogate prediction model from a limited series of observations, the use of surrogates to guide treatment might result in geographic miss. (C) 2004 Elsevier Inc.