Nucleolar hypertrophy correlates with hepatocellular carcinoma development in cirrhosis due to HBV infection
Nucleolar hypertrophy correlates with hepatocellular carcinoma development in cirrhosis due to HBV infection
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DOI：
10.1053/jhep.2003.50039
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发表时间：
2003-01-01
期刊：
影响因子：
13.5
通讯作者：
Derenzini, M
中科院分区：
文献类型：
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作者：
Trerè, D;Borzio, M;Derenzini, M
肝硬化患者患肝细胞癌 (HCC) 的风险很高。本研究的目的是评估不同原因肝硬化中出现核仁肥大的肝细胞百分比与 HCC 发展之间的关系。共有 111 名肝硬化患者接受研究，平均随访时间为 83.3 个月。对肝活检标本的组织学切片进行银染，以选择性地观察核仁；通过图像细胞术测量核仁面积。尺寸为 7 mum(2) 或更大的核仁被认为是肥大的。通过计算核仁面积为 7 mum(2) 或更大的肝细胞的百分比来获得核仁指数。观察期间，111 名患者中有 39 名被诊断为 HCC。核仁指数大于或等于2.5的患者HCC的发生率高于核仁指数小于2.5的患者（分别为16.49%/y vs. 3.41%/y，P
Patients with cirrhosis are at significant risk for hepatocellular carcinoma (HCC). The aim of the present study was to evaluate the relationship between the percentage of hepatocytes showing nucleolar hypertrophy and the development of HCC in cirrhosis of different causes. A total of 111 cirrhotic patients were studied, with a mean follow-up period of 83.3 months. Histologic sections from liver biopsy specimens were silver stained for selective visualization of the nucleolus; the nucleolar area was measured by image cytometry. Nucleoli with a size of 7 mum(2) or greater were considered to be hypertrophic. The nucleolar index was obtained by calculating the percentage of hepatocytes disclosing a nucleolar area of 7 mum(2) or greater. During the observation time, HCC was diagnosed in 39 of 111 patients. The incidence rate of HCC was greater in patients with nucleolar indexes of 2.5 or greater than in patients with nucleolar indexes of less than 2.5 (16.49%/y vs. 3.41%/y, respectively, P