No major association between TGFBR1*6A and prostate cancer.
No major association between TGFBR1*6A and prostate cancer.
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DOI：
10.1186/1471-2156-5-28
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发表时间：
2004-09-22
期刊：
影响因子：
2.9
通讯作者：
Pasche B
中科院分区：
文献类型：
--
作者：
Kaklamani V;Baddi L;Rosman D;Liu J;Ellis N;Oddoux C;Ostrer H;Chen Y;Ahsan H;Offit K;Pasche B
前列腺癌是男性最常见的癌症，也是癌症死亡的主要原因之一。有强有力的遗传证据表明，很大一部分前列腺癌是由遗传因素引起的，但到目前为止，寻找前列腺癌易感基因仍然难以捉摸。TGFBR1*6A是一种常见的I型转化生长因子β受体亚型变异，是一种易患乳腺癌、结肠癌和卵巢癌的肿瘤易感等位基因。与前列腺癌的关系还没有被探索过。对来自纽约市的907名患者和对照组进行了基因分型，以检验TGFBR1*6A可能与前列腺癌发生有关的假设。TGFBR1*6A等位基因频率在病例组(0.086)略高于对照组(0.080)，但TGFBR1*6A等位基因分布在病例组和对照组之间差异无统计学意义(p=0.67)。我们的数据表明，TGFBR1*6A与前列腺癌的发生无关。
Prostate cancer is the most commonly diagnosed cancer in men and one of the leading causes of cancer deaths. There is strong genetic evidence indicating that a large proportion of prostate cancers are caused by heritable factors but the search for prostate cancer susceptibility genes has thus far remained elusive. TGFBR1*6A, a common hypomorphic variant of the type I Transforming Growth Factor Beta receptor, is emerging as a tumor susceptibility allele that predisposes to the development of breast, colon and ovarian cancer. The association with prostate cancer has not yet been explored. A total of 907 cases and controls from New York City were genotyped to test the hypothesis that TGFBR1*6A may contribute to the development of prostate cancer. TGFBR1*6A allelic frequency among cases (0.086) was slightly higher than among controls (0.080) but the differences in TGFBR1*6A genotype distribution between cases and controls did not reach statistical significance (p = 0.67). Our data suggest that TGFBR1*6A does not contribute to the development of prostate cancer.
影响因子：
9.8
作者：
Edwards, SM;Kote-Jarai, Z;Eeles, RA
通讯作者：
Eeles, RA
影响因子：
45.3
作者：
Kaklamani, VG;Hou, NJ;Pasche, B
通讯作者：
Pasche, B
影响因子：
158.5
作者：
Lichtenstein, P;Holm, NV;Hemminki, K
通讯作者：
Hemminki, K