Solution structure of the BRK domains from CHD7
Solution structure of the BRK domains from CHD7
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DOI：
10.1016/j.jmb.2007.06.007
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发表时间：
2007-08-31
影响因子：
5.6
通讯作者：
Bycroft, Mark
中科院分区：
文献类型：
--
作者：
Allen, Mark D.;Religa, Tomasz L.;Bycroft, Mark
CHD7是atp依赖性染色质重塑酶中染色质解旋酶DNA结合域（CHD）家族的一员。它在CHARGE综合征中发生突变，这是一种多发性先天性异常病症。CHD7是冠心病蛋白的一个子集，是含有BRK结构域的后生动物所特有的，BRK结构域也存在于Brahma/BRG1解旋酶家族中。我们在这里描述了CHD7的两个BRK结构域的核磁共振溶液结构。每个域都有一个紧凑或折叠。第二个结构域有一个由两个附加螺旋组成的c端扩展。该结构不同于染色质相关蛋白中存在的其他结构域。
CHD7 is a member of the chromodomain helicase DNA binding domain (CHD) family of ATP-dependent chromatin remodelling enzymes. It is mutated in CHARGE syndrome, a multiple congenital anomaly condition. CHD7 is one of a subset of CHD proteins, unique to metazoans that contain the BRK domain, a protein module also found in the Brahma/BRG1 family of helicases. We describe here the NMR solution structure of the two BRK domains of CHD7. Each domain has a compact or a[ fold. The second domain has a C-terminal extension consisting of two additional helices. The structure differs from those of other domains present in chromatin-associated proteins.