Long-term outcome of epilepsy surgery: A retrospective study in a population of 379 cases
Long-term outcome of epilepsy surgery: A retrospective study in a population of 379 cases
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癫痫手术的长期结果：379 例人群的回顾性研究
DOI：
10.1016/j.eplepsyres.2013.12.004
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发表时间：
2014-03-01
影响因子：
2.2
通讯作者：
Shen, Hong
中科院分区：
文献类型：
--
作者：
Yu, Shengkun;Lin, Zhiguo;Shen, Hong
我们评估了难治性癫痫患者癫痫手术的远期结果，并调查了与术后远期手术结果相关的术前因素。我们对2000年至2010年间接受癫痫手术的379名患者进行了回顾性研究。患者已经完成了至少2年和最长12年的随访。收集和分析患者的术前评估、手术结果和临床资料。我们发现癫痫手术对于耐药患者是有效的，而且癫痫手术的远期效果令人满意。当致痫灶位于功能性皮质时，双极电凝术可改善手术效果。2年随访结果显示，术前癫痫发作特征，包括发热性发作史、发作频率、发作灶的位置、数量和范围与手术疗效显著相关。包括手术类型和切除范围在内的手术方式也会影响预后。头部或海马区MRI异常、术前检查结果不一致、癫痫发作类型和病理类型也可能是长期手术结果的预测因素。2014爱思唯尔B.V.版权所有。
We evaluated the long-term outcome of epilepsy surgery in drug-resistant epilepsy patients, and investigated preoperative factors associated with postoperative long-term surgical outcome. We performed a retrospective study of 379 patients who received epilepsy surgeries from 2000 to 2010. Patients had completed a minimum of 2-year and up to 12-year follow-up. Preoperative evaluations, surgical outcomes and clinical data of patients were collected and analyzed. We found that the epilepsy surgery was effective in drug-resistant patients and the long-term outcome of epilepsy surgery was satisfactory. The bipolar electro-coagulation could improve the surgical outcome when the epileptogenic focus was on the functional cortex. Results of the 2-year follow-up showed that preoperative seizure characteristics including the history of febrile seizure, seizure frequency, and location, quantity and range of seizure foci were significantly associated with the surgical outcome. The surgery procedure including the surgery type and the extent of resection also affected outcome. Abnormal head or hippocampus MRI, inconsistent results of preoperative investigations, seizure types, and pathology type might also be predictors of long-term surgical outcome. 2014 Elsevier B.V. All rights reserved.