Characteristic expression of fukutin in gastric cancer among atomic bomb survivors
Characteristic expression of fukutin in gastric cancer among atomic bomb survivors
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DOI：
10.3892/ol.2016.5520
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发表时间：
2017-02-01
期刊：
影响因子：
2.9
通讯作者：
Yasui, Wataru
中科院分区：
文献类型：
--
作者：
Pham, Trang T. B.;Oue, Naohide;Yasui, Wataru
自在长崎和广岛投下原子弹以来，大约70年过去了。为了阐明潜在的生物标志物和辐射诱发癌症的可能机制，在原子弹幸存者的胃癌（GC）组织样本中分析了编码fuketamine蛋白并导致福山型先天性肌营养不良症的FKTN的表达。还评估了分化簇（CD）10的表达，因为先前已经观察到，在CD 10阳性GC病例中经常观察到阳性fuklatin表达。在来自广岛红十字会医院和原子弹爆炸幸存者医院（日本广岛; n=92）的第一队列中，102例（53%）胃癌病例为福氏杆菌阳性。fukastatin的表达与暴露状态无关，但与CD 10表达相关（P=0.0001）。第二个队列来自广岛大学医院（广岛，日本; n=86），这些患者也在寿命研究队列中，其中使用DS 02系统精确估计原子弹辐射剂量。58例（67%）胃癌组织中检测到fuka的表达。在低剂量暴露组中观察到的福克拉霉素阳性GC病例比高剂量暴露组更频繁（P=0.0001）。更大队列的进一步研究，包括精确的辐射剂量估计，可能有助于澄清是否fuklidine可以作为一个潜在的生物标志物，以定义辐射诱导的GC在原子弹爆炸幸存者。
Approximately 70 years have passed since the atomic bombs were dropped on Nagasaki and Hiroshima. To elucidate potential biomarkers and possible mechanisms of radiation-induced cancer, the expression of FKTN, which encodes fukutin protein and causes Fukuyama-type congenital muscular dystrophy, was analyzed in gastric cancer (GC) tissue samples from atomic bomb survivors. Expression of cluster of differentiation (CD) 10 was also evaluated, as it has previously been observed that positive fukutin expression was frequently noted in CD10-positive GC cases. In the first cohort from Hiroshima Red Cross Hospital and Atomic-Bomb Survivors Hospital (Hiroshima, Japan; n=92),102 (53%) of the GC cases were positive for fukutin. Expression of fukutin was not associated with exposure status, but was associated with CD10 expression (P=0.0001). The second cohort was from Hiroshima University Hospital (Hiroshima, Japan; n=86), and these patients were also in the Life Span Study cohort, in which atomic bomb radiation doses were precisely estimated using the DS02 system. Expression of fukutin was detected in 58 (67%) of GC cases. GC cases positive for fukutin were observed more frequently in the low dose-exposed group than in the high dose-exposed group (P=0.0001). Further studies with a larger cohort, including precise radiation dose estimation, may aid in clarifying whether fukutin could serve as a potential biomarker to define radiation-induced GC in atomic-bomb survivors.