Maitotoxin stimulat es the formation of inositol phosphates in rat aortic myocytes
Maitotoxin stimulat es the formation of inositol phosphates in rat aortic myocytes
复制标题
麦芽毒素刺激大鼠主动脉肌细胞磷酸肌醇的形成
DOI：
10.1016/0014-5793(86)80355-6
复制
发表时间：
1986
期刊：
影响因子：
3.5
通讯作者：
J. Haiech
中科院分区：
文献类型：
--
作者：
Philippe Berta;Fritz Sladeczek;J. Derancourt;M. Durand;P. Travo;J. Haiech
Maitotoxin Maitotoxin Maitotoxin Maitotoxin Maitotoxin maito毒素Maitotoxin maito毒素乳酸菌毒素对肌肉收缩或激素释放的影响与其对电压敏感通道的作用一致。事实上，硝苯地平或地尔硫卓等钙拮抗剂能够逆转maittoxin的作用。利用平滑肌细胞，我们分析了麦麸毒素对肌醇磷酸代谢的影响。Maitotoxin刺激肌醇磷酸的形成（在10 mM LiCI存在下的5±1.8倍）。此外，这种作用不会被钙拮抗剂和α1拮抗剂逆转，甚至部分逆转，也不会被Ca2+离子载体（如A23187）或钙激动剂（如Bay‐K 8644）所模仿。本文进一步讨论了乳酸菌毒素的作用。
Maitotoxin is the most potent of the known marine toxins. The effect of maitotoxin on muscle contraction or hormone release was consistent with its action on the voltage‐sensitive channel. Indeed, calcium antagonists such as nifedipine or diltiazem were able to reverse the maitotoxin effects. Using smooth muscle cells, we have analysed the effects of maitotoxin on the inositol phosphate metabolism. Maitotoxin stimulates the inositol phosphate formation (5 ± 1.8‐fold in the presence of 10 mM LiCI). Moreover, this effect is not reversed, even partially by calcium antagonists, by α1antagonists and is not mimicked by Ca2+ionophores such as A23187 or calcium agonists such as Bay‐K 8644. The action of maitotoxin is further discussed in this paper.