Prognostic value of exercise EKG testing in asymptomatic normotensive subjects. A prospective matched study.
Prognostic value of exercise EKG testing in asymptomatic normotensive subjects. A prospective matched study.
复制标题
运动心电图测试对无症状血压正常受试者的预后价值。
DOI：
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发表时间：
1983
影响因子：
158.5
通讯作者：
G. Folli
中科院分区：
文献类型：
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作者：
E. Giagnoni;M. B. Secchi;S. C. Wu;A. Morabito;L. Oltrona;S. Mancarella;N. Volpin;L. Fossa;L. Bettazzi;G. Arangio;A. Sachero;G. Folli
我们前瞻性地研究了135名无症状的血压正常的受试者，这些受试者的ST段缺血性压低大于或等于1 mm，并与379名对照组进行了比较。对于每个病例，至少选择两个运动心电图(EKG)试验阴性的对照组，并在年龄、性别、工作、社区和冠状动脉危险因素指数方面进行匹配。研究的终点是以下冠状动脉事件：心绞痛、心肌梗死和猝死。在病例和对照组的中位随访期分别为6.0年和6.4年后，相对危险度为5.55(95%可信区间，2.75至11.22)。冠脉事件发生的时间在病例组明显早于对照组。我们的数据还表明，运动EKG反应是心肌梗死的一个特别好的预后指标。此外，我们的分析证实了年龄、吸烟、血压和冠状动脉危险因素指数的预测作用，并表明运动EKG反应是冠状动脉事件的另一个独立危险指标。
We prospectively studied 135 asymptomatic normotensive subjects with exercise-induced ST ischemic depression of 1 mm or more and compared them with 379 controls. At least two controls with negative responses on the exercise electrocardiographic (EKG) test were selected for each case and were matched for age, sex, work, community, and coronary-risk-factors index. The end points considered were the following coronary events: angina pectoris, myocardial infarction, and sudden death. After a median follow-up period of 6.0 years for the cases and 6.4 years for the controls, the relative risk was 5.55 (95 per cent confidence limits, 2.75 to 11.22). Coronary events occurred significantly earlier in the cases than in the controls. Our data also suggest that the exercise EKG response is a particularly good prognostic indicator for myocardial infarction. In addition, our analysis has confirmed the predictive roles of age, smoking, blood pressure, and the coronary-risk-factors index and suggests that the exercise EKG response is an additional independent risk indicator for coronary events.