RNA folding and ribosome assembly.

RNA folding and ribosome assembly.
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DOI:
10.1016/j.cbpa.2008.09.024
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发表时间:
2008-12
影响因子:
7.8
通讯作者:
Woodson, Sarah A.
Woodson, Sarah A.
中科院分区:
生物学2区
文献类型:
--
作者:
Woodson, Sarah A.

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核糖体合成是一个严格调控的过程,对细胞存活至关重要。化学足迹、质谱和低温电子显微镜正在揭示这些复杂的细胞机器是如何组装的。rRNA的快速折叠为细菌30S核糖体的蛋白质诱导组装提供了平台。多个组装途径增加了组装过程的灵活性,而辅助因子和修饰酶陪伴组装的后期阶段并控制成熟亚基的质量。
Ribosome synthesis is a tightly regulated process that is crucial for cell survival. Chemical footprinting, mass spectrometry and cryo-electron microscopy are revealing how these complex cellular machines are assembled. Rapid folding of the rRNA provides a platform for protein-induced assembly of the bacterial 30S ribosome. Multiple assembly pathways increase the flexibility of the assembly process, while accessory factors and modification enzymes chaperone the late stages of assembly and control the quality of the mature subunits.
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