Evidence for Sorption as a Mechanism of the Olfactory Analysis of Vapours
Evidence for Sorption as a Mechanism of the Olfactory Analysis of Vapours
复制标题
吸附作为蒸气嗅觉分析机制的证据
作者：
M. M. Mozell
嗅觉辨别的生理基础可能至少涉及两种不必相互排斥的基本机制：(a)受体本身可能或多或少地选择性地对不同种类的化学物质敏感；(b)受体片作为一个整体，可以通过类似于气相色谱柱的吸附或吸收方式分离化学蒸气。有一些证据支持第一种机制，最近也报道了第二种机制的暗示性证据。第二种机制的证据部分依赖于通过记录两个嗅神经分支（一个外侧分支和一个内侧分支）的放电来从青蛙嗅觉粘膜的不同区域取样，在解剖显微镜下，这两个分支似乎隶属于不同的粘膜区域。最近的电刺激实验证实了这些分支确实服务于不同的粘膜区域。通过放置在上皮上的几个点的电极记录了对外侧和内侧神经分支的个别刺激的反向传导放电。两个分支的放电束是完全分离和局部化的（图1）。
THE physiological basis for olfactory discrimination may involve at least two basic mechanisms which need not be mutually exclusive : (a) the receptors themselves may be more or less selectively sensitive to different groups of chemicals ; (b) the receptor sheet as a whole might separate chemical vapours by adsorption or absorption in a manner analogous to gas chromatography columns. There has been some supporting evidence for the first mechanism1,2, and suggestive evidence for the second has recently been reported3. The evidence suggesting the second mechanism depends, in part, on sampling the activity from different regions of the frog olfactory mucosa by recording the discharges from two olfactory nerve branches (a lateral one and a medial one), which under a dissecting microscope appear to subserve different mucosal regions. That these branches do indeed subserve different mucosal regions is supported by recent electrical stimulation experiments. The antidromically conducted discharges in response to individual stimulation of the lateral and medial nerve branches were recorded by an electrode placed at several points on the epithelium. The discharge tracts for the two branches were quite separate and localized (Fig. 1).