Structural brain abnormalities in bipolar affective disorder. Ventricular enlargement and focal signal hyperintensities.
Structural brain abnormalities in bipolar affective disorder. Ventricular enlargement and focal signal hyperintensities.
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DOI：
10.1001/archpsyc.1990.01810230070011
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发表时间：
1990-11
影响因子：
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通讯作者：
V. Swayze;N. Andreasen;R. Alliger;J. Ehrhardt;W. Yuh
中科院分区：
文献类型：
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作者：
V. Swayze;N. Andreasen;R. Alliger;J. Ehrhardt;W. Yuh
对48例双相情感障碍患者进行了脑结构异常检查，并与54例精神分裂症患者和47例正常对照者进行了比较。与我们之前使用计算机断层扫描的工作一样，侧脑室扩大是由于诊断作用。在这项研究中，这种影响在精神分裂症男性中更为突出，而在双相情感障碍男性中则有这种趋势。两组中的女性与正常受试者没有显着差异。这一发现可能与男性出生异常（如脑积水）的频率较高的事实相一致。由于脑室周围出血或梗死可能是导致出生异常的原因之一，我们还评估了所有扫描中是否存在小的局灶性高信号区。与正常受试者相比，双相情感障碍患者局灶性高信号的数量显著增加，但精神分裂症患者没有。有局灶性高信号的双相情感障碍患者的心室大小比无局灶性高信号的患者有增大的趋势。这些发现的病理生理学意义尚不清楚。
Structural brain abnormalities were examined in a sample of 48 patients with bipolar affective disorder who were compared with 54 schizophrenic patients and 47 normal controls. As in our previous work using computed tomographic scanning, lateral ventricular enlargement was due to a diagnostic effect. In this study, the effect was more prominent in the schizophrenic men, while a trend was seen in the bipolar men. Women in both groups did not differ significantly from normal subjects. This finding is possibly consistent with the fact that men have a higher frequency of birth anomalies such as hydrocephalus. Since one cause of such birth anomalies might be periventricular hemorrhage or infarction, we also evaluated all scans for the presence of small focal regions of signal hyperintensity. A significant increase in the number of focal signal hyperintensities was noted in the bipolar patients, in comparison with normal subjects, but not in the schizophrenics. The bipolar patients with focal signal hyperintensities had a trend toward larger ventricular size than those without. The pathophysiological significance of these findings is unclear.