Proton spectroscopic imaging of the thalamus in treatment-naive pediatric obsessive-compulsive disorder
Proton spectroscopic imaging of the thalamus in treatment-naive pediatric obsessive-compulsive disorder
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DOI：
10.1016/s0006-3223(99)00286-3
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发表时间：
2000-02-01
影响因子：
10.6
通讯作者：
Rosenberg, DR
中科院分区：
文献类型：
--
作者：
Fitzgerald, KD;Moore, GJ;Rosenberg, DR
背景：右侧丘脑，特别是丘脑背内侧核的神经生物学异常被认为与强迫症的病理生理学有关。尽管强迫症通常在儿童期和青少年期发病，但之前没有研究对儿童强迫症患者的丘脑进行检查。
方法：在本研究中，使用多层质子磁共振波谱成像序列，对11例8 - 15岁未接受治疗、无抑郁的强迫症门诊患者以及11例匹配的对照受试者的左右丘脑外侧和内侧亚区的N - 乙酰天门冬氨酸（一种假定的神经元活力标志物）、肌酸/磷酸肌酸和胆碱水平进行了测量。
结果：与对照受试者相比，强迫症患者左右内侧丘脑的N - 乙酰天门冬氨酸/胆碱以及N - 乙酰天门冬氨酸/（肌酸/磷酸肌酸 + 胆碱）显著降低。在左右外侧丘脑，病例 - 对照对之间的N - 乙酰天门冬氨酸/胆碱以及N - 乙酰天门冬氨酸/（肌酸/磷酸肌酸 + 胆碱）水平无显著差异。左侧内侧丘脑N - 乙酰天门冬氨酸水平的降低与强迫症症状严重程度的增加呈负相关。
结论：这些发现为儿童强迫症患者丘脑局部功能性神经化学标志物异常提供了新的证据。然而，鉴于样本量较小，我们的结果必须被视为初步的。《生物精神病学》2000年，47卷，174 - 182页（C）2000生物精神病学学会
Background: Neurobiological abnormalities in rite thalamus, particularly the dorsomedial nucleus of the thalamus, are believed to be involved in the pathophysiology of obsessive-compulsive disorder. Although obsessive-compulsive disorder commonly arises in childhood and adolescence, no prior study has examined the thalamus in pediatric obsessive-compulsive disorder patients.Methods: In this study, N-acetyl-aspartate, a putative marker of neuronal viability, creatine/phosphocreatine, and choline levels were measured in the lateral and medial subregions of the left and right thalami using a multislice proton magnetic resource spectroscopic imaging sequence in 11 treatment-naive, nondepressed obsessive-compulsive disorder outpatients, 8-15 years old, and 11 case-matched control subjects.Results: A significant reduction in N-acetyl-aspartate/choline and N-acetyl-aspartate/(creatine/phosphocreatine + choline) was observed in both the right and left medial thalami in obsessive compulsive disorder patients compared with control subjects. The N-acetyl-aspartate/choline and N-acetyl-aspartate/(creatine/phosphocreatine + choline) levels did nor differ significantly between case-control pairs in either rite left or the right lateral thalamus. Reduction in N-acetyl-aspartate levels in the left menial thalamus was inversely correlated with increased obsessive-compulsive disorder symptom severity.Conclusions: These findings provide new evidence of localized functional neurochemical marker abnormalities ill the thalamus in pediatric obsessive-compulsive disorder, Our results must be considered preliminary, however, given the small sample size. Biol Psychiatry 2000, 47, 174-182 (C) 2000 Society of Biological Psychiatry.