Method for the three-dimensional localization of intramyocardial excitation centers using optical imaging.
Method for the three-dimensional localization of intramyocardial excitation centers using optical imaging.
复制标题
使用光学成像对心肌内激励中心进行三维定位的方法。
DOI：
10.1117/1.2204030
复制
发表时间：
2006
影响因子：
3.5
通讯作者：
Pertsov,ArkadyM
中科院分区：
文献类型：
--
作者：
Khait,VadimD;Bernus,Olivier;Mironov,SergeyF;Pertsov,ArkadyM
本研究探讨了使用电压敏感染料（荧光或吸收）定位心脏壁内电波激发中心的可能性。在本研究中，我们提出了一种方法的3-D本地化的激发中心对2-D图像中获得的两种观察模式：反射和transillumination。这样的图像可以获得使用高速电荷耦合器件（CCD）相机和光电二极管阵列的时间分辨率高达。为了测试该方法，我们模拟了点源产生的光信号和在厚的心肌组织中传播的椭球波。利用镜像法和Robin边界条件构造了光学扩散方程的解。该算法可以精确地确定点源的坐标和扩展波的中心。该方法可以推广到扩展波外边界的深度估计。深度估计基于空间集成图像的比率。该方法对噪声有很高的容忍度，即使在相对较低的信噪比下也能给出准确的结果。总之，我们提出了一种新的和有效的算法在3-D心脏组织的兴奋中心的定位。
This study explores the possibility of localizing the excitation centers of electrical waves inside the heart wall using voltage-sensitive dyes (fluorescent or absorptive). In the present study, we propose a method for the 3-D localization of excitation centers from pairs of 2-D images obtained in two modes of observation: reflection and transillumination. Such images can be obtained using high-speed charge-coupled device (CCD) cameras and photodiode arrays with time resolution up to. To test the method, we simulate optical signals produced by point sources and propagating ellipsoidal waves in-thick slabs of myocardial tissue. Solutions of the optical diffusion equation are constructed by employing the method of images with Robin boundary conditions. The coordinates of point sources as well as of the centers of expanding waves can be accurately determined using the proposed algorithm. The method can be extended to depth estimations of the outer boundaries of the expanding wave. The depth estimates are based on ratios of spatially integrated images. The method shows high tolerance to noise and can give accurate results even at relatively low signal-to-noise ratios. In conclusion, we propose a novel and efficient algorithm for the localization of excitation centers in 3-D cardiac tissue.