SUBCLASS RESTRICTION OF MURINE ANTIBODIES .2. THE IGG PLAQUE-FORMING CELL RESPONSE TO THYMUS-INDEPENDENT TYPE-1 AND TYPE-2 ANTIGENS IN NORMAL MICE AND MICE EXPRESSING AN X-LINKED IMMUNODEFICIENCY
SUBCLASS RESTRICTION OF MURINE ANTIBODIES .2. THE IGG PLAQUE-FORMING CELL RESPONSE TO THYMUS-INDEPENDENT TYPE-1 AND TYPE-2 ANTIGENS IN NORMAL MICE AND MICE EXPRESSING AN X-LINKED IMMUNODEFICIENCY
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DOI：
10.1084/jem.151.4.853
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发表时间：
1980-01-01
影响因子：
15.3
通讯作者：
DAVIE, JM
中科院分区：
文献类型：
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作者：
SLACK, J;DERBALIAN, GP;DAVIE, JM
根据胸腺依赖性和刺激免疫缺陷小鼠品系 CBA/N 的能力，先前将抗原分为 3 类：胸腺依赖性 (TD)、胸腺非依赖性型 (TI) 1 和 TI-2。不同的抗原类别引发不同亚类的Ig[免疫球蛋白]G抗体。 TD 抗原主要刺激 IgG1 抗体，同时表达少量 IgG2 和 IgG3。 TI-1 抗原几乎不刺激 IgG1 抗体，而是刺激等量的 IgG2 和 IgG3。 TI-2 抗原主要引发 IgG3 抗体。表达 CBA/N 表型的小鼠对 TI-2 抗原无反应。这在本研究中得到了证实。在表达 CBA/N 表型的小鼠中，对 TI-1 抗原反应的 IgG3 成分实际上不存在，这支持了之前的发现，即 CBA/N 缺陷可能仅限于包含大多数 IgG3 分泌细胞前体的 B[骨髓来源]淋巴细胞亚群。
Antigens were classified previously into 3 categories, thymus-dependent (TD), thymus-independent type (TI) 1, and TI-2, based upon thymic dependence and ability to stimulate an immunodeficient strain of mouse, CBA/N. The different antigen classes elicited Ig[immunoglobulin]G antibodies of different subclasses. TD antigens stimulate predominantly IgG1 antibodies, with smaller amounts of IgG2 and IgG3 being expressed. TI-1 antigens stimulate almost no IgG1 antibodies and equal amounts of IgG2 and IgG3. TI-2 antigens elicited predominantly IgG3 antibodies. Mice expressing the CBA/N phenotype are nonresponsive to TI-2 antigens. This was confirmed in this study. The IgG3 component of the response to TI-1 antigens was virtually absent in mice expressing the CBA/N phenotype, which supports the previous finding that the CBA/N defect may be restricted to a B[bone marrow-derived]-lymphocyte subpopulation containing most of the precursors of IgG3-secreting cells.