Complications associated with therapeutic neck radiation
Complications associated with therapeutic neck radiation
复制标题
DOI：
10.1016/s0278-2391(96)90254-2
复制
发表时间：
1996-12-01
影响因子：
1.9
通讯作者：
Wang, CC
中科院分区：
文献类型：
--
作者：
August, M;Wang, J;Wang, CC
目的：这项回顾性研究的患者谁接受颈部放射治疗的口腔鳞状细胞癌的治疗的一部分，试图确定和量化的发病率与此treatment.Patients和方法：35例患者接受颈部放射1985年和1992年之间被随机召回检查。所有患者均接受放射肿瘤科的标准化治疗。测量颈部放射对皮肤变化、甲状腺功能、颈部活动范围、颈动脉粥样硬化性疾病、口干症和声门结构的长期影响。57%的患者表现出1级皮肤变化，未观察到严重变化，并且没有观察到继发性瘤形成的发展，辐射剂量和皮肤变化之间没有观察到线性趋势。14.3%的患者在治疗后3.5年内发生甲状腺功能减退症。Logistic回归分析显示甲状腺功能减退症与辐射剂量之间存在显著相关性。颈部活动受限是最显著的并发症，在所有活动范围内均表现出缺陷。在14.3%的患者中记录了颈动脉杂音，N+病例中颈部剂量较高与颈动脉杂音显著相关。68%的患者出现口干。有持续性声门红斑11.4%的patients.Conclusions：这项研究的结果表明，颈部放射后，有持续的并发症，其中包括颈部运动的限制，甲状腺功能减退，加速颈动脉狭窄，皮肤和唾液的变化。
Purpose: This retrospective study of patients who underwent neck radiation as part of their treatment for squamous cell carcinoma of the oral cavity sought to identify and quantify the morbidity associated with this treatment.Patients and Methods: Thirty-five patients who received neck radiation between 1985 and 1992 were randomly recalled for examination. All patients had been treated in a standardized fashion by the Department of Radiation Oncology, The long-term effects of neck radiation on skin changes, thyroid function, and neck range of motion, of atherosclerotic carotid artery disease, xerostomia, and glottic structures were measured.Results: Fifty-seven percent of patients demonstrated grade 1 skin changes, No severe changes were noted, and no development of secondary neoplasia was observed., There was no linear trend observed between radiation dose and skin changes. Hypothyroidism developed in 14.3% of patients within 3.5 years posttreatment. Logistic regression demonstrated a significant association between hypothyroidism and radiation dose. Limitation of neck mobility was the most significant complication with deficits demonstrated in all ranges of motion. Carotid bruits were documented in 14.3% of patients, with a significant association between the higher neck dosage in N+ cases. Xerostomia was found in 68% of patients. There was persistent glottic erythema in 11.4% of patients.Conclusions: The results of this study indicate that there are persistent complications after neck radiation, which include limitation of neck movement, diminished thyroid function, accelerated carotid artery narrowing, and skin and salivary changes.