Both the hippocampus and striatum are involved in consolidation of motor sequence memory
Both the hippocampus and striatum are involved in consolidation of motor sequence memory
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DOI：
10.1016/j.neuron.2008.02.008
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发表时间：
2008-04-24
期刊：
影响因子：
16.2
通讯作者：
Maquet, Pierre
中科院分区：
文献类型：
--
作者：
Albouy, Genevieve;Sterpenich, Virginie;Maquet, Pierre
采用功能磁共振成像（fMRI）研究运动序列记忆巩固的脑相关因素。参与者在进行内隐动眼序列学习任务训练时以及30分钟、5小时或24小时后进行的单次测试期间接受扫描。在训练过程中，海马体和纹状体中观察到的反应与过夜观察到的性能增益呈线性相关，但不是一天。在这两个结构的反应显着更大，在24小时比在30分钟或5小时。此外，在训练过程中观察到这些结构之间的竞争性相互作用成为合作过夜。这些结果强调了海马和纹状体在程序性记忆巩固中的重要性。在训练过程中，这些区域的反应似乎决定了与它们功能相互作用的变化相关的过夜记忆处理。这些结果表明，这两种结构在运动序列巩固过程中相互作用，以优化随后的行为。
Functional magnetic resonance imaging (fMRI) was used to investigate the cerebral correlates of motor sequence memory consolidation. Participants were scanned while training on an implicit oculomotor sequence learning task and during a single testing session taking place 30 min, 5 hr, or 24 hr later. During training, responses observed in hippocampus and striatum were linearly related to the gain in performance observed overnight, but not over the day. Responses in both structures were significantly larger at 24 hr than at 30 min or 5 hr. Additionally, the competitive interaction observed between these structures during training became cooperative overnight. These results stress the importance of both hippocampus and striatum in procedural memory consolidation. Responses in these areas during training seem to condition the overnight memory processing that is associated with a change in their functional interactions. These results show that both structures interact during motor sequence consolidation to optimize subsequent behavior.