Relationship of prolactin response to d-fenfluramine to behavioral and questionnaire assessments of aggression in personality-disordered men
Relationship of prolactin response to d-fenfluramine to behavioral and questionnaire assessments of aggression in personality-disordered men
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DOI：
10.1016/0006-3223(95)00398-3
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发表时间：
1996-08-01
影响因子：
10.6
通讯作者：
Hauger, RL
中科院分区：
文献类型：
--
作者：
Coccaro, EF;Berman, ME;Hauger, RL
催乳素（PRL）对5-羟色胺（5-HT）激发/摄取抑制剂d-芬氟拉明（PRL[d-FEN]）急性激发的反应与14名男性人格障碍受试者的三种不同的攻击措施相关。与以前的工作一致，PRL[d-FEN]反应与Buss-Durkee敌意量表-攻击量表得分呈负相关此外，PRL[d-FEN]反应与攻击行为的直接实验室测量呈负相关。（减点攻击范式：虽然所有的攻击性指标都与PRL[d-FEN]反应相关，但这些指标之间的相关性存在差异。BGA-R攻击性得分与BDHI-Assault和PSAP得分均相关，但BDHI-Assault和PSAP得分之间无相关性。结果表明，中央5-HT功能可能与自我报告和攻击行为的行为措施，这可能代表一些独立的方面的攻击行为。
Prolactin (PRL) responses to acute challenge with the serotonin (5-HT) releaser/uptake inhibitor, d-fenfluramine (PRL[d-FEN]), were correlated with three different measures of aggression in 14 male personality-disordered subjects. Consistent with previous work, PRL[d-FEN] responses were inversely correlated with scores on the Buss-Durkee Hostility Inventory-Assault scale (BDHI-Assault) and with the Brown-Goodwin Aggression - Revised (BGA-R) Aggression scale, In addition, PRL[d-FEN] responses were inversely correlated with a direct laboratory measure of aggressive behavior (Point-Subtraction Aggression Paradigm: PSAP), Although all measures of aggression correlated with PRL[d-FEN] response, differences among the intercorrelations of these measures were found. Specifically, BGA-R Aggression scores correlated with both BDHI-Assault and PSAP scores, but no relation was found between BDHI-Assault and PSAP scores. The results suggest that central 5-HT function may be associated with both self-report and behavioral measures of aggressive behavior, which may represent somewhat separate aspects of aggressive behavior.