Intracellular signaling following myocardial stretch:: an autocrine/paracrine loop
Intracellular signaling following myocardial stretch:: an autocrine/paracrine loop
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DOI：
10.1016/j.regpep.2004.12.011
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发表时间：
2005-06-30
影响因子：
--
通讯作者：
de Hurtado, MCC
中科院分区：
文献类型：
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作者：
Cingolani, HE;Pérez, NG;de Hurtado, MCC
成人乳头肌的牵张引起一系列的自分泌/旁分泌事件，其中Na+/H+交换器（NHE-1）的激活是核心步骤。这种激活是由血管紧张素II-内皮素（Ang II-ET）的连续释放诱导的，并导致细胞内Na+（Na-1（+））的增加，而细胞内pH值没有显著变化。Na+的增加使Na+/Ca 2+交换器（NCX）的反向电位负移，从而诱导细胞Ca 2+内流，增强心肌收缩力。这种力的增加代表了由拉伸触发的自分泌/旁分泌机制的机械对应物，并且被称为对拉伸的慢力反应（SFR）。(c)2004 Elsevier B. V.保留所有权利。
The stretch of adult papillary muscle elicits a chain of autocrine/paracrine events in which the Na+/H+ exchanger (NHE-1) activation is the central step. This activation is induced by a sequential angiotensin II-endothelin (Ang II-ET) release and results in an increase in intracellular Na+ (Na-i(+)) without significant changes in intracellular pH. The increase in Nai+ negatively shifts the reverse potential of the Na+/Ca2+ exchanger (NCX) thus inducing cell Ca2+ influx that augments myocardial contractility. This increase in force represents the mechanical counterpart of the autocrine/paracrine mechanism triggered by stretch and has been called the slow force response (SFR) to stretch. (c) 2004 Elsevier B.V. All rights reserved.