No association of GSK3beta gene (GSK3B) with Japanese schizophrenia.
No association of GSK3beta gene (GSK3B) with Japanese schizophrenia.
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发表时间：
2005
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通讯作者：
M. Ikeda;N. Iwata;Tatsuyo Suzuki;T. Kitajima;Y. Yamanouchi;Y. Kinoshita;N. Ozaki
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作者：
M. Ikeda;N. Iwata;Tatsuyo Suzuki;T. Kitajima;Y. Yamanouchi;Y. Kinoshita;N. Ozaki
有证据表明糖原合成酶激酶3 β（GSK3 β）是精神分裂症易感因子之一。然而，尚未报道基于连锁不平衡（LD）的GSK 3 β基因（GSK 3B）与日本精神分裂症之间的关联分析。我们使用相对较大的样本（381名精神分裂症患者和352名对照者）在确定“标签单核苷酸多态性（SNP）”后进行关联分析。在这个LD作图中，我们选择了8个多态性（7个SNP和1个双等位基因（CAA）（n）重复）并进行了基因分型，这些多态性覆盖了GSK 3B的整个区域，并确定了2个标签SNP。在以下使用这两个“标签SNP”的关联分析中，我们无法发现与日本精神分裂症的关联。此外，我们还包括考虑发病年龄和亚型的亚组分析，我们也没有发现相关性。由于我们的样本提供了相当高的功率，这些结果表明，GSK3B可能不会发挥重要作用，在日本精神分裂症。
Several lines of evidence indicate that glycogen synthase kinase-3beta (GSK3beta) is one of the candidates for schizophrenia-susceptibility factor. However, it has not been reported the association analysis between GSK3beta gene (GSK3B) and Japanese schizophrenia based on linkage disequilibrium (LD). We provide an association analysis using relatively large samples (381 schizophrenia, and 352 controls) after determination of "tag single nucleotide polymorphisms (SNPs)." In this LD mapping, we selected and genotyped for eight polymorphisms (seven SNPs and one diallelic (CAA)(n) repeat), which covered the entire region of GSK3B, and determined two "tag SNPs." In the following association analysis using these two "tag SNPs," we could not find association with Japanese schizophrenia. Furthermore, we also include subgroup analysis considering age-at-onset and subtypes, neither could we find associations. Because our samples provided quite high power, these results indicate that GSK3B may not play a major role in Japanese schizophrenia.