Cancer in first-degree relatives and risk of testicular cancer in Denmark.
Cancer in first-degree relatives and risk of testicular cancer in Denmark.
复制标题
丹麦一级亲属的癌症和睾丸癌的风险。
DOI：
10.1002/ijc.25897
复制
发表时间：
2011
影响因子：
6.4
通讯作者：
Raaschou-Nielsen,Ole
中科院分区：
文献类型：
--
作者：
Nordsborg,RikkeBaastrup;Meliker,JaymieR;Wohlfahrt,Jan;Melbye,Mads;Raaschou-Nielsen,Ole
睾丸癌的家族聚集性一直有报道，但睾丸癌风险与家族中其他癌症之间是否存在任何关联尚不清楚。我们进行了一项基于人群的病例对照研究，以检查睾丸癌风险与一级亲属中22种不同癌症之间的关系。我们纳入了1991年至2003年间丹麦癌症登记处报告的3,297例睾丸癌病例。从丹麦民事登记系统中选择了6，594名匹配的对照，该系统还提供了病例和对照的40，104名一级亲属的身份。通过与丹麦癌症登记处的联系确定了家族性癌症，我们使用条件logistic回归分析一级亲属中的癌症是否与睾丸癌的高风险相关。与无家族性睾丸癌相比，父亲睾丸癌的发生率为4.63（95% CI：2.41-8.87），兄弟睾丸癌的发生率为8.30（95% CI：3.81-18.10），儿子睾丸癌的发生率为5.23（95% CI：1.35-20.26）。当按睾丸癌的组织学亚型进行分层分析时，结果相似。家族性非霍奇金淋巴瘤和食管癌与睾丸癌相关;然而，这些可能是偶然发现。睾丸癌和其他可能的癌症的家族聚集性可以用共享的基因和/或共享的环境因素来解释，但这些因素的相互重要性很难确定。
Familial aggregation of testicular cancer has been reported consistently, but it is less clear if there is any association between risk of testicular cancer and other cancers in the family. We conducted a population‐based case–control study to examine the relationship between risk of testicular cancer and 22 different cancers in first‐degree relatives. We included 3,297 cases of testicular cancer notified to the Danish Cancer Registry between 1991 and 2003. A total of 6,594 matched controls were selected from the Danish Civil Registration System, which also provided the identity of 40,104 first‐degree relatives of case and controls. Familial cancer was identified by linkage to the Danish Cancer Registry, and we used conditional logistic regression to analyze whether cancer among first‐degree relatives was associated with higher risk of testicular cancer. Rate ratio for testicular cancer was 4.63 (95% CI: 2.41–8.87) when a father, 8.30 (95% CI: 3.81–18.10) when a brother and 5.23 (95% CI: 1.35–20.26) when a son had testicular cancer compared to no familial testicular cancer. Results were similar when analyses were stratified by histologic subtypes of testicular cancer. Familial non‐Hodgkin lymphoma and esophageal cancer were associated with testicular cancer; however, these may be chance findings. The familial aggregation of testicular and possibly other cancers may be explained by shared genes and/or shared environmental factors, but the mutual importance of each of these is difficult to determine.