Impact of Smoking Exposure Change on Infant Birth Weight Among a Cohort of Women in a Prenatal Smoking Cessation Study
Impact of Smoking Exposure Change on Infant Birth Weight Among a Cohort of Women in a Prenatal Smoking Cessation Study
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DOI：
10.1093/ntr/nts184
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发表时间：
2013-03-01
影响因子：
4.7
通讯作者：
Stotts, Angela
中科院分区：
文献类型：
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作者：
Benjamin-Garner, Ruby;Stotts, Angela
尽管知道怀孕期间吸烟有害，但高度上瘾的人发现很难戒烟。减少吸烟可被视为减少危害的一种手段。除了戒烟之外，关于减少吸烟的益处的信息有限。本研究使用唾液可替宁来评估吸烟暴露对足月婴儿出生体重变化的影响。在一项产前戒烟研究中，在基线和妊娠结束时通过唾液可替宁（EOP）来验证吸烟状况。唾液可替宁15ng/ml定义主动吸烟。根据唾液可替宁水平，女性在基线和EOP时被分为不吸烟/戒烟、轻度暴露（< 150ng/ml）和重度暴露（150ng/ml）。EOP和基线吸烟状况分层形成吸烟暴露改变组。比较了戒烟、减少体重、维持体重和增加体重的人的平均出生体重。与持续大量吸烟相比，戒烟与出生体重增加299克相关，p .021。与持续的重度暴露相比，从重度暴露到轻度暴露的减少与出生体重增加199g有关，与增加暴露相比增加了103g，与持续的轻度暴露相比增加了63g。持续吸烟者之间的差异没有统计学意义。虽然没有统计学上的显著性，但婴儿出生体重的增加与从重度暴露到轻度暴露的减少有关，这表明了潜在的益处。唯一有统计学意义的比较是在戒烟者和长期重度吸烟者之间，这证实了戒烟应该仍然是孕妇的目标。
Despite the known harmful effects of smoking during pregnancy, the highly addicted find it difficult to quit. Decreased smoking may be regarded as a means of harm reduction. There is limited information on the benefits of smoking reduction short of quitting. This study used salivary cotinine to assess the impact of change in smoking exposure on birth weight in full-term infants.In a prenatal smoking cessation study, smoking status was validated by saliva cotinine at baseline and end of pregnancy (EOP). Salivary cotinine epsilon 15ng/ml defined active smoking. Based on salivary cotinine, women were grouped as nonsmoking/quit, light exposure (< 150ng/ml), and heavy exposure (epsilon 150ng/ml) at baseline and EOP. EOP and baseline smoking status were stratified to form smoking exposure change groups. Mean birth weight was compared among those who quit, reduced, maintained, and increased.Smoking cessation was associated with a 299g increase in birth weight compared with sustained heavy smoking, p .021. Reduced exposure from heavy to light was associated with a 199g increase in birth weight compared with sustained heavy exposure, a 103g increase compared with increased exposure, and a 63g increase compared with sustained light exposure. Differences among continuing smokers were not statistically significant.Although not statistically significant, the increase in infant birth weight associated with reduction from heavy to light exposure suggests potential for benefit. The only statistically significant comparison was between quitters and sustained heavy smokers, confirming that smoking cessation should remain the goal for pregnant women.