Physical inactivity and insufficient dietary intake are associated with the frequency of sarcopenia in patients with compensated viral liver cirrhosis
Physical inactivity and insufficient dietary intake are associated with the frequency of sarcopenia in patients with compensated viral liver cirrhosis
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DOI：
10.1111/hepr.12085
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发表时间：
2013-12-01
影响因子：
4.2
通讯作者：
Habu, Daiki
中科院分区：
文献类型：
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作者：
Hayashi, Fumikazu;Matsumoto, Yoshinari;Habu, Daiki
目的肌减少症与营养状况的关系是肝硬化患者的一个重要问题。在这项研究中，我们调查了营养因素是否与肝硬化患者的肌肉减少症。MethodsThe subjects是50例肝硬化患者，年龄41岁或以上。在这项研究中，受试者接受了关于他们饮食习惯的采访，并使用计步器调查了他们的日常体力活动。采用生物电阻抗法测量骨骼肌质量（ASM），计算骨骼肌质量指数（SMI）。使用手部测力计测量握力。肌肉减少症定义为SMI和握力。将肝硬化患者分为正常组和肌肉减少组，并进行比较。单变量和多变量logistic回归模型用于确定肝硬化患者肌肉减少症的相关性。（比值比（OR），5.336; 95%置信区间[CI]，1.063-26.784; P=0.042），能量摄入/理想体重（IBW）步数（OR，4.767; 95%CI，1.066 -21.321; P= 0.041）和运动量（OR，5.882; 95%CI，1.063-32.554; P= 0.042）是肌少症的独立相关因素。此外，一个显着更多的患者在肌肉减少症组有两个参数的能量摄入量每IBW和steps.ConclusionOur的研究结果表明，步行5000或更多的步骤，每天和维持30千卡/IBW的总能量摄入量可以作为一个参考的生活方式指南代偿性厌食症患者。
AimThe association between sarcopenia and nutritional status is thought to be an important problem in patients with cirrhosis. In this study, we investigated whether nutritional factors were related to sarcopenia in patients with liver cirrhosis.MethodsThe subjects were 50 patients with cirrhosis aged 41 years or older. In this study, the subjects were interviewed about their dietary habits, and their daily physical activity was surveyed using a pedometer. The skeletal muscle mass index (SMI) was calculated using the appendicular skeletal muscle mass (ASM) measured by bioelectric impedance analysis. The handgrip strength was measured using a hand dynamometer. Sarcopenia was defined by SMI and handgrip strength. The patients with cirrhosis were categorized as normal group or sarcopenia group, and the two groups were compared. Univariate and multivariate logistic regression modeling were used to identify the relevance for sarcopenia in patients with cirrhosis.ResultsHeight (odds ratio (OR), 5.336; 95% confidence interval [CI], 1.063-26.784; P=0.042), energy intake per ideal bodyweight (IBW) (OR, 5.882; 95% CI, 1.063-32.554; P=0.042) and number of steps (OR, 4.767; 95% CI, 1.066-21.321; P=0.041) were independent relevant factors for sarcopenia. Moreover, a significantly greater number of the patients in the sarcopenia group had low values for both parameters' energy intake per IBW and number of steps.ConclusionOur results suggest that walking 5000 or more steps per day and maintaining a total energy intake of 30kcal/IBW may serve as a reference for lifestyle guidelines for compensated cirrhotic patients.