Regeneration of dorsal column axons after spinal cord injury in young rats
Regeneration of dorsal column axons after spinal cord injury in young rats
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DOI：
10.1016/s0304-3940(98)00406-6
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发表时间：
1998-06-19
影响因子：
2.5
通讯作者：
Koshinaga, M
中科院分区：
文献类型：
--
作者：
Kikukawa, S;Kawaguchi, S;Koshinaga, M
与以前的报道否认发生轴突再生的背柱（DC）的预测，在这里，我们首次证明，显着的再生发生自发横断后，在婴儿大鼠。横切是尖锐的，以产生无水肿的病变，没有随后形成疤痕或囊肿。轴突的Transganglionic标记显示，再生的轴突上升在正常道中的方式类似于正常的预测作为一个紧密包装的束，并终止于薄核密集。目前的研究表明，DC轴突再生的失败既不是由于再生潜力的内在缺陷，也不是由于全球ly-inhabitable轴突环境，而是由于损伤部位的局部条件。(C)1998爱思唯尔科学爱尔兰有限公司保留所有权利。
In contrast to previous reports denying the occurrence of axonal regeneration of the dorsal column (DC) projections, here we demonstrate for the first time that marked regeneration occurs spontaneously after transection in infant rats. Transection was made sharply so as to produce edema-free lesions without subsequent formation of either scars or cysts. Transganglionic labeling of axons revealed that regenerated axons ascended in the normal tract in a manner similar to normal projections as a tightly-packed fasciculus and terminated densely in the nucleus gracilis. The present study indicates that failure of regeneration of DC axons is due to neither intrinsic deficiency of regrowth potential nor global ly-inhospitable axonal environment but rather the local conditions of the lesion site. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.