Chronic psychosocial stress enhances vasopressin, but not corticotropin-releasing factor, in the external zone of the median eminence of male rats: relationship to subordinate status.
Chronic psychosocial stress enhances vasopressin, but not corticotropin-releasing factor, in the external zone of the median eminence of male rats: relationship to subordinate status.
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慢性心理社会压力会增强雄性大鼠正中隆起外部区域的加压素，但不会增强促肾上腺皮质激素释放因子：与从属地位的关系。
DOI：
10.1210/endo.131.2.1322285
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发表时间：
1992
期刊：
影响因子：
4.8
通讯作者：
F. Tilders
中科院分区：
文献类型：
--
作者：
D. C. de Goeij;H. Dijkstra;F. Tilders
研究慢性社会心理应激对雄性Wistar大鼠下丘脑-垂体-肾上腺系统的影响。将群居的下属与雌雄成对的对照大鼠进行比较。慢性应激的经典参数（胸腺退化、躯体生长受损和静息血浆皮质酮水平升高）在所有下属大鼠中均被发现。应用定量免疫细胞化学方法测定大鼠中位隆起外区血管加压素（AVP）和CRF的变化。慢性社会心理压力持续19-28天，使ZEME的AVP免疫染色增加到配对对照组的160-190%，而ZEME的CRF免疫染色保持不变。在群体内，下属在回避行为和受到的攻击（下属地位）方面存在差异。ZEME群体内隶属等级与AVP呈显著相关（P < 0.01）。虽然小鼠静息时皮质酮升高（P < 0.01），但阻断轴突运输后，AVP的升高与ZEME中可检测到的AVP和/或CRF分泌无关。在对照大鼠中，与优势雄鼠的相互作用增加了血浆ACTH和皮质酮水平，并导致ZEME中AVP的消耗，而不是CRF。下属在与优势雄性相互作用时表现出下丘脑（AVP耗竭）、垂体（血浆ACTH）和肾上腺（血浆皮质酮）的抑制反应，这可能反映了皮质酮升高对CRF神经元或下丘脑上中枢的抑制作用。
Male Wistar rats living in hierarchically structure male/female colonies were used to investigate the effects of chronic psychosocial stress on the hypothalamus-pituitary-adrenal system. Colony-housed subordinates were compared to control rats housed in male-female pairs. Classical parameters of chronic stress (thymus involution, impaired somatic growth, and elevated resting plasma corticosterone level) were found in all subordinate rats. Changes in vasopressin (AVP) and CRF stored in the external zone of the median eminence (ZEME) were measured by quantitative immunocytochemistry. Chronic psychosocial stress for 19-28 days increased AVP immunostaining in the ZEME to 160-190% of that in pair-housed controls, whereas CRF immunostaining in the ZEME remained unchanged. Within colonies, subordinates differed in avoidance behavior and aggression received (subordinate status). This intracolony subordination rank was correlated with AVP in the ZEME (P less than 0.01). Although resting corticosterone was elevated in subordinate rats (P less than 0.01), the increase in AVP was not associated with detectable secretion of AVP and/or CRF from the ZEME, as measured after blockade of axonal transport. In control rats, interaction with a dominant male increased plasma ACTH and corticosterone levels and caused depletion of AVP, but not CRF, from the ZEME. Subordinates showed suppressed hypothalamic (AVP depletion), pituitary (plasma ACTH) and adrenal (plasma corticosterone) responses to interaction with the dominant male, which may reflect suppressive actions of elevated corticosterone on CRF neurons or suprahypothalamic centers.
促肾上腺皮质激素释放因子刺激促肾上腺皮质激素和β-内啡肽释放：急性和慢性应激的影响。
影响因子：
4.8
作者：
Young,EA;Akil,H
通讯作者：
Akil,H