Ligands with dual vitamin D3-agonistic and androgen-antagonistic activities
Ligands with dual vitamin D3-agonistic and androgen-antagonistic activities
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DOI：
10.1016/j.bmcl.2005.06.044
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发表时间：
2005-10-01
影响因子：
2.7
通讯作者：
Hashimoto, Y
中科院分区：
文献类型：
--
作者：
Hosoda, S;Tanatani, A;Hashimoto, Y
基于取代的二苯甲烷骨架，制备了具有维生素D-3激动（估计为HL-60单核细胞分化诱导）和雄激素拮抗（估计为睾酮诱导的SC-3细胞生长抑制）双重活性的配体，其具有各种活性谱。其中一些被发现是有效的雄激素拮抗剂与nonsecosteroidal维生素D-3骨架。(c)2005爱思唯尔有限公司保留所有权利。
Ligands possessing dual vitamin D-3-agonistic (estimated as HL-60 monocytic cell differentiation induction) and androgen-antagonistic (estimated as testosterone-induced SC-3 cell growth inhibition) activities with various activity spectra were prepared based on a substituted bis-phenylmethane skeleton. Some of them were revealed to be potent androgen antagonists with a nonsecosteroidal vitamin D-3 skeleton. (c) 2005 Elsevier Ltd. All rights reserved.