Investigation of an amyloid precursor protein protective mutation (A673T) in a North American case-control sample of late-onset Alzheimer's disease.
Investigation of an amyloid precursor protein protective mutation (A673T) in a North American case-control sample of late-onset Alzheimer's disease.
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DOI：
10.1016/j.neurobiolaging.2014.01.020
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发表时间：
2014-07
影响因子：
4.2
通讯作者：
Kamboh MI
中科院分区：
文献类型：
--
作者：
Bamne MN;Demirci FY;Berman S;Snitz BE;Rosenthal SL;Wang X;Lopez OL;Kamboh MI
一种罕见的淀粉样前体蛋白（APP）基因变体A673T（rs63750847）最近被报道可以预防冰岛人的阿尔茨海默病（AD）和与年龄相关的认知能力下降，在芬兰，挪威和瑞典人群中也观察到了同样的罕见变体。我们在1，674例迟发性AD病例和2，644例老年对照中研究了这种变异，所有北美白人（美国白人）。在我们的大样本中，我们没有观察到任何A673T变体的例子。我们的研究结果表明，这种罕见的变异可能是特定于北欧国家的起源的个人。
A rare amyloid precursor protein (APP) gene variant, A673T (rs63750847) was recently reported to protect against Alzheimer’s disease (AD) and age-related cognitive decline among Icelanders and the same rare variant was observed also in Finnish, Norwegian, and Swedish populations. We investigated this variant in 1,674 late-onset AD cases and 2,644 elderly controls, all North American Whites (U.S. Whites). We did not observe any example of the A673T variant in our large sample. Our findings suggest that this rare variant could be specific to the individuals of the origin from the Nordic countries.
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影响因子：
4.2
作者：
Kero, Mia;Paetau, Anders;Tienari, Pentti J.
通讯作者：
Tienari, Pentti J.
影响因子：
9.9
作者：
Lopez, OL;Becker, JT;DeKosky, ST
通讯作者：
DeKosky, ST
影响因子：
6.8
作者：
Kamboh MI;Demirci FY;Wang X;Minster RL;Carrasquillo MM;Pankratz VS;Younkin SG;Saykin AJ;Alzheimer's Disease Neuroimaging Initiative;Jun G;Baldwin C;Logue MW;Buros J;Farrer L;Pericak-Vance MA;Haines JL;Sweet RA;Ganguli M;Feingold E;Dekosky ST;Lopez OL;Barmada MM
通讯作者：
Barmada MM
影响因子：
120.7
作者：
DeKosky, Steven T.;Williamson, Jeff D.;Fitzpatrick, Annette L.;Kronmal, Richard A.;Ives, Diane G.;Saxton, Judith A.;Lopez, Oscar L.;Burke, Gregory;Carlson, Michelle C.;Fried, Linda P.;Kuller, Lewis H.;Robbins, John A.;Tracy, Russell P.;Woolard, Nancy F.;Dunn, Leslie;Snitz, Beth E.;Nahin, Richard L.;Furberg, Curt D.
通讯作者：
Furberg, Curt D.
影响因子：
64.8
作者：
Jonsson, Thorlakur;Atwal, Jasvinder K.;Stefansson, Kari
通讯作者：
Stefansson, Kari