Influence of the location of nasal polyps on olfactory airflow and olfaction
Influence of the location of nasal polyps on olfactory airflow and olfaction
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DOI：
10.1002/alr.22089
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发表时间：
2018-06-01
影响因子：
6.4
通讯作者：
Yamasoba, Tatsuya
中科院分区：
文献类型：
--
作者：
Nishijima, Hironobu;Kondo, Kenji;Yamasoba, Tatsuya
背景：慢性鼻窦炎伴鼻息肉（CRSwNP）常导致嗅觉减退。在这项研究中，我们研究了鼻息肉的位置和嗅觉气流和气味传输的变化之间的关系，使用虚拟鼻息肉模型在不同的位置和计算流体动力学（CFD）分析。我们还使用CFD分析和嗅觉测试比较了不同部位鼻息肉患者的嗅觉气流和嗅觉。方法：鼻计算机断层扫描图像用于生成正常模型和4个基于息肉位置的虚拟鼻息肉模型，包括嗅觉区域（全嗅觉模型）、嗅觉区前面的区域（前嗅觉模型）、中鼻道（中鼻道模型）和上级鼻道（上级鼻道模型）。比较了这些模型与没有息肉的正常模型之间的各种气流参数。然后，我们进行了类似的比较与鼻息肉患者的三维（3D）重建模型，并回顾性地研究了嗅觉和鼻息肉的位置在这些patients.Results：虚拟鼻息肉分析之间的相关性揭示了分散的嗅觉气流在全嗅觉模型。嗅觉气流和气味物质的运输表现出最大的下降，在前嗅觉模型和上鼻道模型略有下降。通过阻塞嗅觉气流入口比阻塞出口，息肉的嗅觉气流进一步减少。结论：鼻息肉的位置对嗅气流和嗅觉功能有不同的影响。这一发现对于从改善患者嗅觉的角度规划息肉切除手术是重要的。(C)2018 ARS-AAOA，LLC.
Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) often results in decreased olfaction. In this study, we examined the relationship between nasal polyp location and olfactory airflow and odorant transport changes using virtual nasal polyp models at different locations and computational fluid dynamics (CFD) analysis. We also compared olfactory airflow and olfaction between patients with nasal polyps at different locations using CFD analysis and an olfactory test.Methods: Nasal computed tomography images were used to generate a normal model and 4 virtual nasal polyp models based on polyp locations, including the olfactory region (all-olfactory model), the region anterior to the olfactory region (preolfactory model), the middle meatus (middle-meatus model), and the superior meatus (superior-meatus model). Various airflow parameters were compared between these models and a normal model without polyps. We then performed a similar comparison between the 3-dimensional (3D) reconstruction models of patients with nasal polyps, and retrospectively investigated the correlation between olfaction and nasal polyp location in those patients.Results: Virtual nasal polyp analysis revealed dispersion of olfactory airflow in the all-olfactory model. Olfactory airflow and odorant transport showed maximum decrease in the preolfactory model and a slight decrease in the superior-meatus model. Olfactory airflow by polyps was further decreased by blockade of the olfactory airflow inlet than of the outlet. The findings obtained by patients corresponded well to those of the virtual polyp analysis.Conclusion: Olfactory airflow and olfaction are differentially affected by nasal polyp location. This finding is important for planning polyp-removal surgeries from the perspective of improving patient olfaction. (C) 2018 ARS-AAOA, LLC.