Glucose-dependent insulinotropic polypeptide may enhance fatty acid re-esterification in subcutaneous abdominal adipose tissue in lean humans.
Glucose-dependent insulinotropic polypeptide may enhance fatty acid re-esterification in subcutaneous abdominal adipose tissue in lean humans.
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作者：
Asmar M;Simonsen L;Madsbad S;Stallknecht B;Holst JJ;Bülow J
葡萄糖依赖性胰岛素多肽（GIP）与动物脂质代谢有关。然而，在人类中，没有明确的证据表明GIP影响脂质代谢。本实验旨在阐明GIP对局部脂肪组织代谢的影响。8名健康受试者在4个不同场合进行了研究。在GIP （1.5 pmol/kg/min）或单独静脉滴注生理盐水或联合高胰岛素-高血糖（HI-HG）钳期间，通过测量动静脉浓度差异和区域脂肪组织血流量来评估腹部皮下脂肪组织代谢。与生理盐水和HI-HG钳夹相比，GIP和HI-HG钳夹期间腹部皮下脂肪组织血流量、循环三酰甘油（TAG）水解（P = 0.009）和葡萄糖摄取（P = 0.03）显著增加，游离脂肪酸（FFA）输出（P = 0.04）和FFA/甘油释放比（P = 0.02）显著降低。综上所述，GIP合并高胰岛素血症和轻度高血糖会增加脂肪组织血流量、葡萄糖摄取和FFA再酯化，从而导致腹部皮下脂肪组织中TAG沉积增加。
Glucose-dependent insulinotropic polypeptide (GIP) has been implicated in lipid metabolism in animals. In humans, however, there is no clear evidence of GIP effecting lipid metabolism. The present experiments were performed in order to elucidate the effects of GIP on regional adipose tissue metabolism. Eight healthy subjects were studied on four different occasions. Abdominal subcutaneous adipose tissue metabolism was assessed by measuring arterio-venous concentration differences and regional adipose tissue blood flow during GIP (1.5 pmol/kg/min) or saline infused intravenously alone or in combination with a hyperinsulinemic-hyperglycemic (HI-HG) clamp. During GIP and HI-HG clamp, abdominal subcutaneous adipose tissue blood flow, hydrolysis of circulating triacylglycerol (TAG) (P = 0.009), and glucose uptake (P = 0.03) increased significantly while free fatty acid (FFA) output (P = 0.04) and FFA/glycerol release ratio (P = 0.02) decreased compared with saline and HI-HG clamp. In conclusion, GIP in combination with hyperinsulinemia and slight hyperglycemia increased adipose tissue blood flow, glucose uptake, and FFA re-esterification, thus resulting in increased TAG deposition in abdominal subcutaneous adipose tissue.